Song Eyun, Jang Soo Yeon, Park Min Jeong, Jang Ahreum, Kim Kyeong Jin, Yu Ji Hee, Kim Nam Hoon, Yoo Hye Jin, Seo Ji A, Kim Sin Gon, Kim Nan Hee, Baik Sei Hyun, Choi Kyung Mook
Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University Guro Hospital, 80 Guro-Dong, Guro-Gu, Seoul, 152-050, Korea.
Sci Rep. 2025 Jul 31;15(1):28018. doi: 10.1038/s41598-025-13235-5.
Sarcopenia may be associated with suicide through various mechanisms, including depression, physical disability, chronic diseases, and myokines. However, research on this topic has been limited. We analyzed individuals who participated in the Korea National Health and Nutrition Examination Survey from 2008 to 2011 and had available dual-energy X-ray absorptiometry data and information on suicidal ideation. Of the 17,615 individuals, 2,902 (16.5%) were categorized into the suicidal ideation group. Low muscle mass was more prevalent in the suicidal ideation group than in the non-suicidal ideation group (10.8% vs. 7.8%, respectively; p < 0.001). The results of a multiple logistic regression revealed a significantly higher odds ratio (OR) for suicidal ideation in participants with low muscle mass than in those without (OR, 1.25; p = 0.029), after adjusting for various confounding factors. This association was more pronounced in females than in males, and in those aged 50-79 years than in those aged < 50 or ≥ 80 years. Individuals with low muscle mass revealed a substantial association with an increased odd of suicidal ideation in the general Korean population. These results suggest that screening and interventions for sarcopenia may help prevent suicide, particularly among middle-aged females.
肌肉减少症可能通过多种机制与自杀相关，包括抑郁、身体残疾、慢性疾病和肌动蛋白。然而，关于这一主题的研究一直有限。我们分析了2008年至2011年参加韩国国家健康与营养检查调查且有可用双能X线吸收法数据和自杀意念信息的个体。在17615名个体中，2902人（16.5%）被归入自杀意念组。自杀意念组中低肌肉量的患病率高于非自杀意念组（分别为10.8%和7.8%；p<0.001）。多元逻辑回归结果显示，在调整各种混杂因素后，低肌肉量参与者的自杀意念比值比（OR）显著高于无低肌肉量者（OR，1.25；p=0.029）。这种关联在女性中比在男性中更明显，在50至79岁的人群中比在<50岁或≥80岁的人群中更明显。在韩国普通人群中，低肌肉量个体与自杀意念几率增加存在显著关联。这些结果表明，对肌肉减少症进行筛查和干预可能有助于预防自杀，尤其是在中年女性中。
