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小儿腺样体切除术是一种并发症发生率低的安全手术:一项基于人群的研究。

Pediatric adenoidectomy is safe surgery with a low complication rate: a population-based study.

作者信息

Losgar Hannah, Boeger Daniel, Buentzel Jens, Hoffmann Kerstin, Podzimek Jiri, Kaftan Holger, Mueller Andreas, Tresselt Sylvia, Geißler Katharina, Guntinas-Lichius Orlando

机构信息

Department of Otorhinolaryngology, Jena University Hospital, Jena, Germany.

Department of Otorhinolaryngology, Zentralklinikum, Suhl, Germany.

出版信息

Sci Rep. 2025 Jul 31;15(1):27967. doi: 10.1038/s41598-025-13803-9.

DOI:10.1038/s41598-025-13803-9
PMID:40745469
Abstract

Population-based data on incidence of complications after pediatric adenoidectomy are sparse. Therefore, a retrospective population-based study of all 2105 pediatric adenoidectomies (59.9% male, median age: 4 years) in the year 2019 in all otolaryngology departments in one federal state, Thuringia, in Germany, was performed. Patients' and treatment characteristics, and complications were analyzed. The highest surgery rate was seen at the age of 3 years (2747.4 per 100,000 children). Adenoidectomy was combined with tonsillotomy or tonsillectomy in 29.2% and 1.5% of the cases. Postoperative bleeding needing re-surgery occurred in 1.1% of all cases. The revision surgery for bleeding rate after solitary adenoidectomy was 0.7%. A wound infection was seen in 1.0%. Complications classified according to the Clavien-Dindo classification (CDC) occurred in 2.6% of cases. The overall complication rate was 20.3/100,000 population. Additional tonsillectomy was independently associated to bleeding > 24 h after surgery (Odds ratio [OR] = 52.141; confidence interval [CI] = 7.772-349.818; p < 0.0001). There was no independent associative factor to enhanced risk of wound infection. CDC complications occurred more frequently in comorbid patients (OR = 4.175; CI = 1.222-14.271; p = 0.023), underweight children (OR = 2.430; CI = 1.198-6.571; p = 0.040), when additional tonsillectomy was performed (OR = 11.177; CI = 2.098-59.548; p < 0.0001), and when perioperative antibiotics were applied (OR = 13.251; CI = 5.695-30.834; p < 0.001). Adenoidectomy is very safe surgery. Main risk factor for bleeding complications is additional tonsillectomy, not adenoidectomy itself.

摘要

关于小儿腺样体切除术后并发症发生率的基于人群的数据较为稀少。因此,对德国图林根州所有耳鼻喉科在2019年进行的2105例小儿腺样体切除术(男性占59.9%,中位年龄:4岁)进行了一项基于人群的回顾性研究。分析了患者及治疗特征和并发症情况。手术率最高出现在3岁时(每10万名儿童中有2747.4例)。在29.2%和1.5%的病例中,腺样体切除术分别与扁桃体切开术或扁桃体切除术联合进行。所有病例中有1.1%发生了需要再次手术的术后出血。单纯腺样体切除术后出血的再次手术率为0.7%。出现伤口感染的比例为1.0%。根据Clavien-Dindo分类(CDC)分类的并发症发生在2.6%的病例中。总体并发症发生率为每10万人中20.3例。额外的扁桃体切除术与术后出血超过24小时独立相关(比值比[OR]=52.141;置信区间[CI]=7.772 - 349.818;p<0.0001)。没有增加伤口感染风险的独立相关因素。CDC并发症在合并症患者中更频繁发生(OR=4.175;CI=1.222 - 14.271;p=0.023)、体重过轻的儿童中(OR=2.430;CI=1.198 - 6.571;p=0.040)、进行额外扁桃体切除术时(OR=11.177;CI=2.098 - 59.548;p<0.0001)以及应用围手术期抗生素时(OR=13.251;CI=5.695 - 30.834;p<0.001)。腺样体切除术是非常安全的手术。出血并发症的主要危险因素是额外的扁桃体切除术,而非腺样体切除术本身。

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本文引用的文献

1
Adenoidectomy for otitis media with effusion (OME) in children.腺样体切除术治疗儿童分泌性中耳炎(OME)。
Cochrane Database Syst Rev. 2023 Oct 23;10(10):CD015252. doi: 10.1002/14651858.CD015252.pub2.
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Effect of the German tonsillitis guideline on indication for tonsil surgery in patients with recurrent acute tonsillitis: a population-based study.德国扁桃体炎指南对复发性急性扁桃体炎患者扁桃体切除术适应证的影响:一项基于人群的研究。
Sci Rep. 2023 Oct 17;13(1):17612. doi: 10.1038/s41598-023-44661-y.
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Adenoid hypertrophy in children: a narrative review of pathogenesis and clinical relevance.
儿童腺样体肥大:发病机制和临床相关性的叙述性综述。
BMJ Paediatr Open. 2023 Apr;7(1). doi: 10.1136/bmjpo-2022-001710.
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Postoperative morbidity and mortality after adenoidectomy: A national population-based study of 51 746 surgeries.腺样体切除术后的发病情况及死亡率:一项基于全国51746例手术的人群研究。
Int J Pediatr Otorhinolaryngol. 2022 Dec;163:111335. doi: 10.1016/j.ijporl.2022.111335. Epub 2022 Oct 4.
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30-day readmission rate in pediatric otorhinolaryngology inpatients: a retrospective population-based cohort study.儿科耳鼻喉科住院患者 30 天再入院率:一项回顾性基于人群的队列研究。
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[Just method effects? Prevalences of underweight, overweight and obesity in children and adolescents according to the weighting factors and reference system used].[只是方法效应?根据所使用的加权因素和参考系统,儿童和青少年中体重不足、超重和肥胖的患病率]
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2019 Oct;62(10):1235-1241. doi: 10.1007/s00103-019-03011-y.
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Adenotonsillectomy for Obstructive Sleep Apnea and Quality of Life: Systematic Review and Meta-analysis.腺样体扁桃体切除术治疗阻塞性睡眠呼吸暂停与生活质量:系统评价与荟萃分析
Otolaryngol Head Neck Surg. 2017 Nov;157(5):767-773. doi: 10.1177/0194599817717480. Epub 2017 Jul 4.
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Eur Arch Otorhinolaryngol. 2017 Oct;274(10):3627-3635. doi: 10.1007/s00405-017-4655-z. Epub 2017 Jun 26.
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Incidence of second surgery following pediatric adenotonsillar surgery: a population-based cohort study.小儿腺样体扁桃体切除术后二次手术的发生率:一项基于人群的队列研究。
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