外科手术患者体内布洛芬的立体选择性分布
Stereoselective disposition of indoprofen in surgical patients.
作者信息
Björkman S
出版信息
Br J Clin Pharmacol. 1985 Nov;20(5):463-7. doi: 10.1111/j.1365-2125.1985.tb05098.x.
Abstract
The pharmacokinetics of the enantiomers of indoprofen were determined after intravenous administration of the racemate to 10 surgical patients. The mean volume of distribution was 8.97 +/- 2.21 (s.d.) 1 for the pharmacologically active S(+)-enantiomer and 12.60 +/- 4.21 1 for the R(-)-enantiomer (P less than 0.001). The corresponding values for clearance were 32.2 +/- 11.1 ml min-1 and 48.8 +/- 15.5 ml min-1 (P less than 0.001). There was no significant difference in mean terminal half-life between the enantiomers.
摘要
在对10名外科手术患者静脉注射消旋吲哚洛芬后，测定了其对映体的药代动力学。药理活性S(+)-对映体的平均分布容积为8.97±2.21（标准差）升，R(-)-对映体为12.60±4.21升（P<0.001）。相应的清除率值分别为32.2±11.1毫升/分钟和48.8±15.5毫升/分钟（P<0.001）。对映体之间的平均末端半衰期无显著差异。
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