关于西沙必利在人结肠中释放乙酰胆碱作用的反对证据。
Evidence against an acetylcholine releasing action of cisapride in the human colon.
作者信息
Burleigh D E, Trout S J
出版信息
Br J Clin Pharmacol. 1985 Nov;20(5):475-8. doi: 10.1111/j.1365-2125.1985.tb05100.x.
Abstract
The effect of cisapride (R51619) on intrinsic cholinergic nerve activity of human sigmoid taenia coli muscle strips (taenia) was assessed using radiolabelling techniques. Taeniae previously incubated with [3H]-choline were exposed to cisapride (0.41 and 4.1 microM), placebo solution and electrical field stimulation (EFS; 10 Hz, 1 ms, 200 mA for 480 pulses). Cisapride did not affect unstimulated (basal) release of radioactive material nor the release evoked by EFS. It was concluded that cisapride did not demonstrate a cholinomimetic effect in human sigmoid taenia coli muscle strips.
摘要
采用放射性标记技术评估西沙必利（R51619）对人乙状结肠带肌条（结肠带）内在胆碱能神经活性的影响。预先用[3H] - 胆碱孵育的结肠带分别暴露于西沙必利（0.41和4.1微摩尔）、安慰剂溶液和电场刺激（EFS；10赫兹，1毫秒，200毫安，共480个脉冲）。西沙必利不影响放射性物质的未刺激（基础）释放，也不影响EFS诱发的释放。得出的结论是，西沙必利在人乙状结肠带肌条中未表现出拟胆碱作用。
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