西沙必利对豚鼠胃平滑肌自发和诱发电反应的兴奋与抑制作用。

Excitation and inhibition by cisapride of spontaneous and evoked electrical responses in smooth muscles of guinea-pig stomach.

作者信息

Ohno N, Zhang G, Xue L, Yamamoto Y, Itoh M, Suzuki H

机构信息

Department of Physiology, Nagoya City University Medical School, Japan.

出版信息

Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1995 Oct;112(2):145-52. doi: 10.1016/0742-8413(95)02006-3.

DOI:10.1016/0742-8413(95)02006-3

PMID:8788586

Abstract

In isolated circular smooth muscles of the guinea-pig stomach, cisapride depolarized the membrane, increased the amplitude and interval of slow waves, and enhanced the cholinergic excitatory junction potential, with no change in the nonadrenergic noncholinergic inhibitory junction potentials. Methysergide mimicked the excitatory actions of cisapride on junction potentials. Results showed that cisapride has dual actions on gastric muscles; excitation by facilitating the release of ACh possibly via 5-HT receptor blockade and also by depolarizing the smooth muscle membrane, and inhibition by reducing the frequency of slow waves, possibly by acting directly on the pacemakers.

摘要

在豚鼠胃的离体环形平滑肌中，西沙必利使膜去极化，增加慢波的幅度和间隔，并增强胆碱能兴奋性接头电位，而对非肾上腺素能非胆碱能抑制性接头电位无影响。麦角新碱模拟了西沙必利对接头电位的兴奋作用。结果表明，西沙必利对胃肌有双重作用；通过可能经由5-羟色胺受体阻断促进乙酰胆碱释放以及使平滑肌膜去极化而产生兴奋作用，通过可能直接作用于起搏细胞降低慢波频率而产生抑制作用。