Salmon A G, Kerr Muir M, Andersson N
Br J Ind Med. 1985 Dec;42(12):795-8. doi: 10.1136/oem.42.12.795.
Acute toxic effects of methyl isocyanate in the rat were determined for two hour exposures to concentrations in the range 11 ppm (very slight effect) to 65 ppm (lethality: pulmonary oedema). Changes in the eye, lungs, and behaviour were noted. Eye changes were confined to erosions of the corneal epithelium and were most severe at intermediate levels of exposure. A comparison was made of the effects noted in rats with reported effects on survivors of the Bhopal disaster. Urinary thiocyanate concentrations in exposed rats were found to be reduced relative to control values.
通过让大鼠暴露于11 ppm（非常轻微的影响）至65 ppm（致死率：肺水肿）范围内的浓度达两小时，测定了异氰酸甲酯对大鼠的急性毒性作用。记录了眼部、肺部和行为的变化。眼部变化仅限于角膜上皮糜烂，且在中等暴露水平时最为严重。将在大鼠身上观察到的影响与报告的博帕尔灾难幸存者的影响进行了比较。发现暴露大鼠的尿硫氰酸盐浓度相对于对照值有所降低。
