异氰酸甲酯对培养的大鼠脑细胞的影响。

Anderson D, Goyle S, Phillips B J, Tee A, Beech L, Butler W H

British Industrial Biological Research Association, Carshalton, Surrey.

Br J Ind Med. 1990 Sep;47(9):596-601. doi: 10.1136/oem.47.9.596.

Since the disaster in Bhopal, India, people exposed to methyl isocyanate (MIC) have complained of various disorders including neuromuscular dysfunction. In an attempt to get information about such dysfunction we have previously shown that MIC can affect muscle cells in culture. The present communication reports investigations into the effect of MIC on brain cells in culture. MIC was toxic to brain cells and the response was dose related. The observations were supported by light and electron microscopy.

自印度博帕尔灾难发生以来，接触异氰酸甲酯（MIC）的人出现了包括神经肌肉功能障碍在内的各种病症。为了获取有关此类功能障碍的信息，我们之前已表明MIC会影响培养中的肌肉细胞。本通讯报道了对MIC对培养中的脑细胞影响的研究。MIC对脑细胞有毒性，且反应与剂量相关。这些观察结果得到了光学显微镜和电子显微镜的支持。