Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Department of Immunology, Isfahan University of Medical Science, Isfahan, Iran.
Neurol Sci. 2024 Jan;45(1):75-82. doi: 10.1007/s10072-023-07057-4. Epub 2023 Sep 8.
Oceania is a continent, covering more than 8 million km, with a population of more than 44 million people. In different countries landing in Oceania, various prevalence of MS has been reported, so we designed this systematic review and meta-analysis to estimate the pooled prevalence of MS in Oceania.
We systematically searched PubMed, Scopus, EMBASE, Web of Science, and Google Scholar. We also searched references of included studies, and conference abstracts. The search was done on January 1, 2023, by two independent researchers. We extracted the name of the first author, country, publication year, prevalence period, number of study participants, total female and male population, disease duration, type of MS, mean duration of the disease, mean age at disease onset, mean Expanded Disability Status Scale (EDSS), and total female and male patients with MS.
A literature search revealed 81,044 records; after deleting duplicates, 38,260 records remained. One hundred and six full texts were evaluated, and finally, seventeen studies remained for systematic review. Most studies were done in Newcastle; eight studies were done in 1961, 8 in 1981, 2 in 1996, and 2 in 2001. In all other years, only one study was done. The pooled prevalence of MS in 1961 in Oceania was estimated as 19.85/100,000 (I=70.3%, p=0.001). The pooled prevalence of MS in 1981 in Oceania was estimated as 39.07/100,000 (I =88%, p=0.001).
The result of this systematic review and meta-analysis shows that the prevalence of MS has increased dramatically during the timespan in Oceania.
大洋洲是一个大陆，面积超过 800 万平方公里，人口超过 4400 万。在大洋洲的不同国家，报道了各种多发性硬化症的流行率，因此我们设计了这项系统回顾和荟萃分析，以估计大洋洲多发性硬化症的总体流行率。
我们系统地检索了 PubMed、Scopus、EMBASE、Web of Science 和 Google Scholar。我们还检索了纳入研究的参考文献和会议摘要。搜索于 2023 年 1 月 1 日由两名独立研究人员进行。我们提取了第一作者的姓名、国家、出版年份、流行期、研究参与者人数、总女性和男性人口、疾病持续时间、多发性硬化症类型、疾病平均持续时间、疾病平均发病年龄、平均扩展残疾状况量表（EDSS）以及多发性硬化症的总女性和男性患者人数。
文献检索显示有 81044 条记录；删除重复项后，仍有 38260 条记录。评估了 106 篇全文，最终有 17 项研究纳入系统评价。大多数研究是在纽卡斯尔进行的；8 项研究于 1961 年进行，8 项研究于 1981 年进行，2 项研究于 1996 年进行，2 项研究于 2001 年进行。在其他所有年份，仅进行了一项研究。1961 年大洋洲多发性硬化症的总体流行率估计为 19.85/100000（I=70.3%，p=0.001）。1981 年大洋洲多发性硬化症的总体流行率估计为 39.07/100000（I=88%，p=0.001）。
这项系统回顾和荟萃分析的结果表明，在大洋洲的这段时间内，多发性硬化症的流行率显著增加。
