• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

吩噻嗪的可持续电化学膦酰化反应。具有强大抗菌活性的C-鏻甜菜碱的合成。

A sustainable electrochemical phosphonylation of phenothiazine. Synthesis of a C-phosphonium betaine with powerful antibacterial activity.

作者信息

Gitipeimay Hamedani Mahtab, Nematollahi Davood, Goudarztalejerdi Ali, Mohamadighader Niloofar, Lotfipour Farideh

机构信息

Faculty of Chemistry and Petroleum Sciences, Bu-Ali Sina University Hamedan 65178-38683 Iran

Planet Chemistry Research Center, Bu-Ali Sina University Hamedan Iran.

出版信息

RSC Adv. 2025 Jul 31;15(33):27246-27253. doi: 10.1039/d5ra03690a. eCollection 2025 Jul 25.

DOI:10.1039/d5ra03690a
PMID:40746782
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12311779/
Abstract

To demonstrate the capabilities of electrochemistry in the synthesis of organic compounds, we developed a facile and sustainable direct electrochemical phosphonylation of phenothiazine with triphenylphosphine. In this work, we demonstrated that electrochemically produced phenothiazine-5-ium can react with triphenylphosphine in a water/acetonitrile mixture under simple conditions using graphite and stainless steel electrodes in an undivided cell, galvanostatically and without the use of any catalyst, to synthesize the corresponding C-phosphonium betaine in good yield. The synthesized phosphonium betaine shows strong antibacterial activity against a variety of Gram positive and negative bacteria.

摘要

为了展示电化学在有机化合物合成中的能力，我们开发了一种简便且可持续的方法，即吩噻嗪与三苯基膦的直接电化学膦酰化反应。在这项工作中，我们证明了电化学产生的吩噻嗪 -5- 鎓能在水 / 乙腈混合溶剂中，于简单条件下，使用石墨和不锈钢电极在无隔膜电解池中，恒电流且不使用任何催化剂的情况下，与三苯基膦反应，以良好的产率合成相应的 C- 磷鎓甜菜碱。合成的磷鎓甜菜碱对多种革兰氏阳性和阴性细菌表现出强大的抗菌活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3399/12311779/346bbf909edc/d5ra03690a-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3399/12311779/faae5537c601/d5ra03690a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3399/12311779/c3a4f9c3fa53/d5ra03690a-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3399/12311779/bd360e31325d/d5ra03690a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3399/12311779/ebb9f123dd60/d5ra03690a-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3399/12311779/a4db20db3737/d5ra03690a-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3399/12311779/ebe79e225dc0/d5ra03690a-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3399/12311779/2655e510a206/d5ra03690a-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3399/12311779/6dfdce150c5e/d5ra03690a-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3399/12311779/346bbf909edc/d5ra03690a-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3399/12311779/faae5537c601/d5ra03690a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3399/12311779/c3a4f9c3fa53/d5ra03690a-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3399/12311779/bd360e31325d/d5ra03690a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3399/12311779/ebb9f123dd60/d5ra03690a-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3399/12311779/a4db20db3737/d5ra03690a-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3399/12311779/ebe79e225dc0/d5ra03690a-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3399/12311779/2655e510a206/d5ra03690a-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3399/12311779/6dfdce150c5e/d5ra03690a-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3399/12311779/346bbf909edc/d5ra03690a-f6.jpg

相似文献

1
A sustainable electrochemical phosphonylation of phenothiazine. Synthesis of a C-phosphonium betaine with powerful antibacterial activity.吩噻嗪的可持续电化学膦酰化反应。具有强大抗菌活性的C-鏻甜菜碱的合成。
RSC Adv. 2025 Jul 31;15(33):27246-27253. doi: 10.1039/d5ra03690a. eCollection 2025 Jul 25.
2
Phenothiazine Polymers as Versatile Electrode Materials for Next-Generation Batteries.吩噻嗪聚合物作为下一代电池的多功能电极材料
Acc Mater Res. 2025 May 19;6(6):754-764. doi: 10.1021/accountsmr.5c00053. eCollection 2025 Jun 27.
3
Intracavity lavage and wound irrigation for prevention of surgical site infection.腔内灌洗和伤口冲洗预防手术部位感染
Cochrane Database Syst Rev. 2017 Oct 30;10(10):CD012234. doi: 10.1002/14651858.CD012234.pub2.
4
The Effect of Labeling During Simulated Contact on Attitudes Toward Autistic Adults.模拟接触过程中的标签对对待成年自闭症患者态度的影响。
Autism Adulthood. 2025 Feb 5;7(1):93-99. doi: 10.1089/aut.2023.0081. eCollection 2025 Feb.
5
Investigation of the Biological Activity of Pyrrolo[1,2-a]imidazole Derivatives Produced by a Green One-Pot Multicomponent Synthesis of Ninhydrins.茚三酮绿色一锅多组分合成法制备的吡咯并[1,2-a]咪唑衍生物的生物活性研究
Comb Chem High Throughput Screen. 2024 Jun 7. doi: 10.2174/0113862073298187240524053210.
6
Preexisting Diabetes and Pregnancy: An Endocrine Society and European Society of Endocrinology Joint Clinical Practice Guideline.糖尿病合并妊娠：内分泌学会与欧洲内分泌学会联合临床实践指南
J Clin Endocrinol Metab. 2025 Jul 13. doi: 10.1210/clinem/dgaf288.
7
Preexisting Diabetes and Pregnancy: An Endocrine Society and European Society of Endocrinology Joint Clinical Practice Guideline.孕前糖尿病与妊娠：内分泌学会和欧洲内分泌学会联合临床实践指南
Eur J Endocrinol. 2025 Jun 30;193(1):G1-G48. doi: 10.1093/ejendo/lvaf116.
8
Preparation and biological activity of isoperrottetin A and its phosphonium salts derivatives.异珀罗替丁A及其鏻盐衍生物的制备与生物活性
Eur J Pharm Sci. 2025 Jun 11;212:107167. doi: 10.1016/j.ejps.2025.107167.
9
Factors that impact on the use of mechanical ventilation weaning protocols in critically ill adults and children: a qualitative evidence-synthesis.影响重症成人和儿童机械通气撤机方案使用的因素：一项定性证据综合分析
Cochrane Database Syst Rev. 2016 Oct 4;10(10):CD011812. doi: 10.1002/14651858.CD011812.pub2.
10
Orthodontic treatment for crowded teeth in children.儿童牙齿拥挤的正畸治疗。
Cochrane Database Syst Rev. 2021 Dec 31;12(12):CD003453. doi: 10.1002/14651858.CD003453.pub2.

本文引用的文献

1
Stereoselective amino alcohol synthesis via chemoselective electrocatalytic radical cross-couplings.通过化学选择性电催化自由基交叉偶联合成立体选择性氨基醇。
Nat Chem. 2025 Jan;17(1):44-53. doi: 10.1038/s41557-024-01695-7. Epub 2025 Jan 3.
2
Pyrolytic Carbon: An Inexpensive, Robust, and Versatile Electrode for Synthetic Organic Electrochemistry.热解碳：用于合成有机电化学的一种廉价、耐用且多功能的电极
Angew Chem Int Ed Engl. 2025 Jan 21;64(4):e202417122. doi: 10.1002/anie.202417122. Epub 2024 Nov 16.
3
Advancing drug discovery: Thiadiazole derivatives as multifaceted agents in medicinal chemistry and pharmacology.
推进药物发现：噻二唑衍生物作为药物化学和药理学中的多面手
Bioorg Med Chem. 2024 Oct 1;112:117876. doi: 10.1016/j.bmc.2024.117876. Epub 2024 Aug 16.
4
Electrochemical Synthesis of the -oxide Metabolites of Phenothiazine-Containing Antipsychotic Medications.含吩噻嗪类抗精神病药物的 -氧化物代谢物的电化学合成。
Molecules. 2024 Jun 26;29(13):3038. doi: 10.3390/molecules29133038.
5
Electrochemical generation of phenothiazin-5-ium. A sustainable strategy for the synthesis of new bis(phenylsulfonyl)-10H-phenothiazine derivatives.吩噻嗪 -5- 鎓的电化学生成。一种合成新型双（苯磺酰基）-10H-吩噻嗪衍生物的可持续策略。
Sci Rep. 2024 Feb 21;14(1):4276. doi: 10.1038/s41598-024-53620-0.
6
Phenothiazines as anti-cancer agents: SAR overview and synthetic strategies.苯并噻嗪类作为抗癌药物：构效关系概述和合成策略。
Eur J Med Chem. 2023 Jun 5;254:115337. doi: 10.1016/j.ejmech.2023.115337. Epub 2023 Apr 6.
7
Antioxidant Properties of New Phenothiazine Derivatives.新型吩噻嗪衍生物的抗氧化特性
Antioxidants (Basel). 2022 Jul 14;11(7):1371. doi: 10.3390/antiox11071371.
8
Development of Phenothiazine Hybrids with Potential Medicinal Interest: A Review.具有潜在药用价值的吩噻嗪类杂合体的开发：综述。
Molecules. 2022 Jan 3;27(1):276. doi: 10.3390/molecules27010276.
9
Organic Electrochemistry: Molecular Syntheses with Potential.有机电化学：具有潜力的分子合成
ACS Cent Sci. 2021 Mar 24;7(3):415-431. doi: 10.1021/acscentsci.0c01532. Epub 2021 Mar 9.
10
Recent Progress in the Development of New Antimalarial Drugs with Novel Targets.新型抗疟药物靶点研发的最新进展。
Drug Des Devel Ther. 2020 Sep 22;14:3875-3889. doi: 10.2147/DDDT.S265602. eCollection 2020.