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通过给体-受体超分子卟啉中强氧化性光生空穴实现近红外光驱动的高效肿瘤消除

Near-Infrared Light-Driven Efficient Tumor Elimination via Strong Oxidative Photogenerated Holes in Donor-Acceptor Supramolecular Porphyrin.

作者信息

Li Wenting, Jing Jianfang, Wei Ziyu, Xu Jingyi, Shi Wenhao, Wang Huaipeng, Zhu Xiaolin, Du Yan, Wang Yifei, Li Junshan, Zhu Yongfa

机构信息

Department of Chemistry, Tsinghua University, Beijing 100084, China.

College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, China.

出版信息

JACS Au. 2025 Jul 16;5(7):3500-3512. doi: 10.1021/jacsau.5c00535. eCollection 2025 Jul 28.

DOI:10.1021/jacsau.5c00535
PMID:40747056
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12308412/
Abstract

Efficient photocatalytic tumor therapy relies on deep tissue penetration via near-infrared (NIR) light absorption and potent oxidative stress induced by efficient photogenerated hole (h) migration. Herein, we report a supramolecular donor-acceptor (D-A) structure fabricated by integrating self-assembled tetra-(4-carboxyphenyl) porphyrin (SA-TCPP) with amino-functionalized graphene quantum dots (GQDs-NH). The D-A configuration significantly narrowed the band gap for extended NIR absorption and amplified the interfacial electric field 6.2 times. This facilitated efficient h migration with a 5.3-fold enhancement, generating highly oxidation holes. Under 700 nm irradiation, this system induced potent oxidative cell apoptosis, leading to 100% tumor elimination . This study presents a dual-promotion strategy involving NIR responsiveness and charge migration, advancing the efficiency of photocatalytic cancer therapy.

摘要

高效的光催化肿瘤治疗依赖于通过近红外（NIR）光吸收实现的深层组织穿透以及由高效光生空穴（h）迁移诱导的强烈氧化应激。在此，我们报道了一种超分子供体-受体（D-A）结构，它是通过将自组装的四（4-羧基苯基）卟啉（SA-TCPP）与氨基功能化的石墨烯量子点（GQDs-NH）整合而成。D-A构型显著缩小了带隙以实现扩展的近红外吸收，并将界面电场放大了6.2倍。这促进了高效的h迁移，增强了5.3倍，产生了高氧化性空穴。在700nm照射下，该系统诱导了强烈的氧化细胞凋亡，导致肿瘤100%消除。本研究提出了一种涉及近红外响应性和电荷迁移的双重促进策略，提高了光催化癌症治疗的效率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c280/12308412/9b6cc3a2d154/au5c00535_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c280/12308412/5a14bfad7776/au5c00535_0008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c280/12308412/d3423dd39db2/au5c00535_0006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c280/12308412/5a14bfad7776/au5c00535_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c280/12308412/d549e499b79a/au5c00535_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c280/12308412/89f8f6edabbe/au5c00535_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c280/12308412/bbc57270d8ff/au5c00535_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c280/12308412/94d3e1307e34/au5c00535_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c280/12308412/314899f0772e/au5c00535_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c280/12308412/d3423dd39db2/au5c00535_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c280/12308412/9b6cc3a2d154/au5c00535_0007.jpg

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Near-Infrared Light-Driven Efficient Tumor Elimination via Strong Oxidative Photogenerated Holes in Donor-Acceptor Supramolecular Porphyrin.

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本文引用的文献

[1]
Unsymmetric Protonation Driven Highly Efficient HO Photosynthesis in Supramolecular Photocatalysts via One-Step Two-Electron Oxygen Reduction.

Angew Chem Int Ed Engl. 2025-3-3

[2]
Enhancing Built-in Electric Fields via Molecular Symmetry Modulation in Supramolecular Photocatalysts for Highly Efficient Photocatalytic Hydrogen Evolution.

Angew Chem Int Ed Engl. 2024-6-21

[3]
Near-Infrared Light-Driven Photocatalysis with an Emphasis on Two-Photon Excitation: Concepts, Materials, and Applications.

Adv Mater. 2024-2

[4]
Supramolecular Photosensitizer Enables Oxygen-Independent Generation of Hydroxyl Radicals for Photodynamic Therapy.

J Am Chem Soc. 2023-2-13

[5]
Unique Double Intramolecular and Intermolecular Exciton Coupling in Ethene-Bridged aza-BODIPY Dimers for High-Efficiency Near-Infrared Photothermal Conversion and Therapy.

Angew Chem Int Ed Engl. 2022-11-2

[6]
A Bacteria-Responsive Porphyrin for Adaptable Photodynamic/Photothermal Therapy.

Angew Chem Int Ed Engl. 2022-6-7

[7]
Controlling upconversion in emerging multilayer core-shell nanostructures: from fundamentals to frontier applications.

Chem Soc Rev. 2022-3-7

[8]
Photoluminescence mechanism of carbon dots: triggering high-color-purity red fluorescence emission through edge amino protonation.

Nat Commun. 2021-11-25

[9]
Construction of Interfacial Electric Field via Dual-Porphyrin Heterostructure Boosting Photocatalytic Hydrogen Evolution.

Adv Mater. 2022-1

[10]
Photogenerated-hole-induced rapid elimination of solid tumors by the supramolecular porphyrin photocatalyst.

Natl Sci Rev. 2020-7-2

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