Key Lab of Organic Optoelectronics & Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing, 100084, China.
Angew Chem Int Ed Engl. 2022 Jun 7;61(23):e202200799. doi: 10.1002/anie.202200799. Epub 2022 Apr 7.
We report a cationic porphyrin 5,10,15,20-tetrakis-(4-N-methylpyridyl)-porphyrin (TMPyP) that can respond to specific bacteria, followed by adaptable photodynamic/photothermal therapy processes. TMPyP could be reduced to phlorin by facultative anaerobes with a strong reducing ability such as E. coli and S. typhimurium in hypoxic environments, possessing strong NIR absorption and remarkable photothermal conversion capacity, thus demonstrating excellent antimicrobial activity (>99 %) by photothermal therapy. While in an aerobic environment with aerobic bacteria, TMPyP functioned as a typical photosensitizer that killed bacteria effectively (>99.9 %) by photodynamic therapy. By forming a host-guest complex with cucurbit[7]uril, the biocompatibility of TMPyP significantly improved. This kind of bacteria-responsive porphyrin shows specificity and adaptivity in antimicrobial treatment and holds potential in non-invasive treatments of bacterial infections.
我们报告了一种阳离子卟啉 5,10,15,20-四（4-N-甲基吡啶基）卟啉（TMPyP），它可以响应特定的细菌，随后是适应性强的光动力/光热治疗过程。TMPyP 可以在缺氧环境中被具有强还原能力的兼性厌氧菌（如大肠杆菌和伤寒沙门氏菌）还原为叶啉，具有很强的近红外吸收和显著的光热转换能力，因此通过光热治疗表现出优异的抗菌活性（>99%）。而在有氧环境中与需氧菌共存时，TMPyP 作为一种典型的光敏剂，通过光动力治疗有效地杀死细菌（>99.9%）。通过与葫芦[7]脲形成主客体配合物，TMPyP 的生物相容性显著提高。这种细菌响应卟啉在抗菌治疗中表现出特异性和适应性，在细菌感染的非侵入性治疗中具有潜力。
