Gruber Samuel, Houtman Arno, Reisert Hailey, Amini Mina, Fiore Caroline, Gonzalez Paula, Han Veronica, Jazic Aeva, Kusupholnand Mie, Miller Max, Nam Jiung, Wang Ziqin, Yu Yang, Dong Peter, Oak Allen S W, Sharma Arun, Spana Eric P
Department of Biology, Duke University, Durham, North Carolina, United States.
Duke Kunshan University, Kunshan, Jiangsu, China.
MicroPubl Biol. 2025 Jul 16;2025. doi: 10.17912/micropub.biology.001704. eCollection 2025.
The ( ) mutation first described by Morgan and Bridges in 1915 has adult visible phenotypes in wing posture and vein formation. We have mapped to a genomic region within the ( ) gene that houses the cis-regulatory elements that control expression of the Iroquois Complex genes ( ) and ( ) in the wing hinge and wing veins. Sequence analysis of the allele has identified a gtwin retrotransposon containing su(Hw) insulator binding sites within this region of . We find that mutations in suppress the phenotype, providing a potential mechanism for the insertion to affect the function of the Iroquois Complex.
1915年摩根和布里奇斯首次描述的（ ）突变在成虫的翅姿态和翅脉形成方面具有可见表型。我们已将（ ）定位到（ ）基因内的一个基因组区域，该区域包含控制易洛魁复合体基因（ ）和（ ）在翅铰链和翅脉中表达的顺式调控元件。对（ ）等位基因的序列分析在（ ）的该区域内鉴定出一个含有su(Hw)绝缘子结合位点的gtwin逆转座子。我们发现（ ）中的突变抑制了（ ）表型，为该插入影响易洛魁复合体功能提供了一种潜在机制。
