（ ）的（ ）突变定位于位于（ ）基因中的易洛魁复合体（Iro-C）的顺式调控区域。
The ( ) mutation of maps to the cis-regulatory region of the Iroquois Complex (Iro-C) located in the ( gene.
作者信息
Gruber Samuel, Houtman Arno, Reisert Hailey, Amini Mina, Fiore Caroline, Gonzalez Paula, Han Veronica, Jazic Aeva, Kusupholnand Mie, Miller Max, Nam Jiung, Wang Ziqin, Yu Yang, Dong Peter, Oak Allen S W, Sharma Arun, Spana Eric P
机构信息
Department of Biology, Duke University, Durham, North Carolina, United States.
Duke Kunshan University, Kunshan, Jiangsu, China.
出版信息
MicroPubl Biol. 2025 Jul 16;2025. doi: 10.17912/micropub.biology.001704. eCollection 2025.
The ( ) mutation first described by Morgan and Bridges in 1915 has adult visible phenotypes in wing posture and vein formation. We have mapped to a genomic region within the ( ) gene that houses the cis-regulatory elements that control expression of the Iroquois Complex genes ( ) and ( ) in the wing hinge and wing veins. Sequence analysis of the allele has identified a gtwin retrotransposon containing su(Hw) insulator binding sites within this region of . We find that mutations in suppress the phenotype, providing a potential mechanism for the insertion to affect the function of the Iroquois Complex.
1915年摩根和布里奇斯首次描述的（ ）突变在成虫的翅姿态和翅脉形成方面具有可见表型。我们已将（ ）定位到（ ）基因内的一个基因组区域，该区域包含控制易洛魁复合体基因（ ）和（ ）在翅铰链和翅脉中表达的顺式调控元件。对（ ）等位基因的序列分析在（ ）的该区域内鉴定出一个含有su(Hw)绝缘子结合位点的gtwin逆转座子。我们发现（ ）中的突变抑制了（ ）表型，为该插入影响易洛魁复合体功能提供了一种潜在机制。
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