Ivanitskaia Iu G, Sel'kov E E
Biofizika. 1985 Nov-Dec;30(6):1016-21.
A model is developed to investigate the steady state of the glycolytic system of procaryotic cells which have the hexose transport into the cell coupled with phosphoenolpyruvic acid-dependent phosphorylation. Analysis of the model shows that this phosphorylation results: 1) in stoichiometric connection between the rate of hexose consumption and the utilization of ATP and 2) the stoichiometric positive feedback. The latter can be the cause of bistability, oscillations and other nonlinear phenomena.
开发了一个模型来研究原核细胞糖酵解系统的稳态,该系统中己糖转运入细胞与磷酸烯醇丙酮酸依赖性磷酸化相偶联。对该模型的分析表明,这种磷酸化导致:1)己糖消耗速率与ATP利用之间的化学计量联系,以及2)化学计量正反馈。后者可能是双稳态、振荡和其他非线性现象的原因。