Abbasi Ebrahim, Moemenbellah-Fard Mohammad Djaefar
Research Center for Health Sciences, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Biology and Control of Disease Vectors, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
Glob Epidemiol. 2025 Apr 28;9:100202. doi: 10.1016/j.gloepi.2025.100202. eCollection 2025 Jun.
Arboviruses, including Chikungunya (CHIKV), Dengue (DENV), and West Nile (WNV) viruses, are significant viral threats that affect numerous people globally each year. This report explores the prevalence of these viruses in Iran through a systematic review and meta-analysis.
The present survey was performed using a systematic review and meta-analysis method on the seroprevalence of WNV, CHIKV, and DENV using the ELISA test. Accordingly, by searching Web of Science, PubMed, Scopus, Cochrane Library, Science Direct, and Google Scholar scientific databases, all relevant published papers were sorted out and reviewed. Power ratification of data was conducted with a random effects model in meta-analysis, meta-regression, index, and Egger test.
This meta-analysis report embodies twelve published papers between 2000 and 2024. The seroprevalence of positive ELISA tests for WNV in Iran was estimated at 12.9 % (CI = 95 %: 7.4-18.4) and for CHIKV at 6.2 % (CI = 95 %: 0.6-11.8). Regarding DENV, only two studies were conducted, with a zero prevalence in one study and a seroprevalence of 5.6 % in another study.
According to these data, WNV, CHIKV, and DENV fevers have been detected in Iran using the ELISA test. Considering the seropositivity of WNV and CHIKV and their detection in several provinces, it can be assumed that these viruses are ubiquitous, while DENV fever remains sporadic in Iran.
包括基孔肯雅病毒（CHIKV）、登革热病毒（DENV）和西尼罗河病毒（WNV）在内的虫媒病毒是重大的病毒威胁，每年在全球影响众多人群。本报告通过系统评价和荟萃分析探讨这些病毒在伊朗的流行情况。
本调查采用系统评价和荟萃分析方法，对使用酶联免疫吸附测定（ELISA）检测WNV、CHIKV和DENV的血清阳性率进行研究。据此，通过检索科学网、PubMed、Scopus、考克兰图书馆、科学Direct和谷歌学术等科学数据库，整理并审查了所有相关的已发表论文。在荟萃分析、荟萃回归、指标分析和埃格检验中，采用随机效应模型进行数据的功效验证。
本荟萃分析报告纳入了2000年至2024年间发表的12篇论文。伊朗WNV ELISA检测阳性的血清阳性率估计为12.9%（95%置信区间：7.4 - 18.4），CHIKV为6.2%（95%置信区间：0.6 - 11.8）。关于DENV，仅进行了两项研究，一项研究患病率为零，另一项研究血清阳性率为5.6%。
根据这些数据，在伊朗使用ELISA检测已发现WNV、CHIKV和DENV引起的发热。考虑到WNV和CHIKV的血清阳性以及它们在多个省份的检测情况，可以推测这些病毒普遍存在，而DENV发热在伊朗仍然是散发性的。
