Belitser V A, Lugovskoĭ E V, Ugarova T P, Derzskaia S G
Biokhimiia. 1985 Aug;50(8):1336-41.
The inhibitory effect of fibrinogen in the clotting of two fibrin monomer species--f-desAA and f-desAABB--was studied. The concentration dependence of this effect for two fibrin forms was found to be of the same character. This fact indicates that the modifying influence of fibrinogen proposed earlier in relation to f-desAABB also takes place in the case of f-desAA. However, an equal inhibitory effect is achieved for f-desAA at much higher fibrinogen concentrations than that for f-desAABB. The inhibitory effect of fibrinogen is greater at higher ionic strengths for both fibrin forms, but in the case of f-desAA this effect is more pronounced. The role of fibrin polymerization sites formed after fibrinopeptides B removal in initial fibrin polymerization and in F-f-desAABB interaction is discussed.
研究了纤维蛋白原对两种纤维蛋白单体——f-desAA和f-desAABB——凝血的抑制作用。发现这种作用对两种纤维蛋白形式的浓度依赖性具有相同的特征。这一事实表明，先前提出的纤维蛋白原对f-desAABB的修饰作用在f-desAA的情况下也会发生。然而，与f-desAABB相比，f-desAA在高得多的纤维蛋白原浓度下才能达到相同的抑制效果。对于两种纤维蛋白形式，在较高离子强度下纤维蛋白原的抑制作用更大，但在f-desAA的情况下这种作用更为明显。讨论了去除纤维蛋白肽B后形成的纤维蛋白聚合位点在初始纤维蛋白聚合以及F-f-desAABB相互作用中的作用。
