Kilár F, Simon I
Biophys J. 1985 Nov;48(5):799-802. doi: 10.1016/S0006-3495(85)83838-8.
Distance distribution functions, p(r), radii of gyration, Rg, and radii of gyration of cross section, Rq, of apotransferrin, monoferric transferrin, and diferric transferrin have been compared. The alteration of Rg and Rq upon iron binding has been determined by a difference method. An unusual feature of the stepwise structural changes of transferrin upon iron saturation is that binding of the first ferric ion is responsible for more than half of the whole change in Rq, whereas Rg alters significantly only after the binding of the second ferric ion.
已对脱铁转铁蛋白、单铁转铁蛋白和双铁转铁蛋白的距离分布函数p(r)、回转半径Rg以及横截面回转半径Rq进行了比较。通过差值法确定了铁结合后Rg和Rq的变化。转铁蛋白在铁饱和时逐步发生结构变化的一个不寻常特征是，第一个铁离子的结合导致了Rq整体变化的一半以上，而Rg仅在第二个铁离子结合后才发生显著变化。
