Aleksevich Ia I, Tumanov V P, Kovalishin V I, Pavliust L P
Biull Eksp Biol Med. 1985 Dec;100(12):664-8.
Dogs and white rats with experimental tetanus were examined for blood plasma lipids and red cells, their acid resistance, oxygen balance, cytochrome oxidase and aspartate transaminase activity and muscle ultrastructure. The amount of blood plasma lipids was found to be increased, the lipid content in red cells was lowered because of phospholipid washing out. The red cell resistance was lowered, their sedimentation rate was accelerated. Oxygen metabolism in muscles was first enhanced to form excess lipid peroxides, disturbing the integrity of cell membranes and myocyte ultrastructure, and then it was suppressed because of depletion of the compensatory mechanisms and eventuated in the destruction of part of cells and later on in the death of animals.
对患有实验性破伤风的狗和白鼠进行了血浆脂质、红细胞、其耐酸性、氧平衡、细胞色素氧化酶和天冬氨酸转氨酶活性以及肌肉超微结构的检查。发现血浆脂质含量增加，由于磷脂被洗脱，红细胞中的脂质含量降低。红细胞抵抗力降低，其沉降速率加快。肌肉中的氧代谢首先增强，形成过量的脂质过氧化物，扰乱细胞膜和肌细胞超微结构的完整性，然后由于补偿机制耗尽而受到抑制，最终导致部分细胞破坏，随后动物死亡。
