[Lipid peroxidation in the dynamics of experimental toxic adrenal encephalopathy].

TBA-active product plasma content, unsaturated fatty acid level in erythrocyte membrane and peroxide resistance of erythrocytes 1, 7, 15, 30, 45 and 60 days after the onset of experimental toxico-adrenal encephalopathy (ETAE) have been investigated in the peripheral blood of 7 dogs. The first 30 days were characterized by an increase in the indexes indicative of lipid peroxidation (LPO) intensification and a trend towards their further normalization. It is suggested that at early stages of ETAE LPO intensification plays a predominant role in the pathological chemistry of model dystrophic process, while at later stages the leading role is played by other brain metabolism disturbances, associated with LPO activation.