Trinus F P, Pisarev A A, Chubenko A V, Stefanov A V
Biull Eksp Biol Med. 1985 Dec;100(12):714-5.
The experiments on white mice have shown CCl4 to induce 24 hours after its injection focal changes in the liver, such as hepatocyte necrotization accompanied by lell organoid destruction, drastic reduction in glycogen content and increased fat content, as well as considerable decline in the activity of aerobic and anaerobic metabolic enzymes. Liposome administration attenuated the lytic effect of poison, promoting the integrity of subcellular hepatocyte structures. Distrophic changes in the latter led to increased glycogen content lower lipid level and intensified bioenergic processes.
对白鼠的实验表明，四氯化碳在注射后24小时可诱导肝脏出现局灶性变化，如肝细胞坏死并伴有细胞内细胞器破坏、糖原含量急剧减少、脂肪含量增加，以及有氧和无氧代谢酶活性显著下降。脂质体给药减弱了毒物的溶解作用，促进了肝细胞亚细胞结构的完整性。后者的营养不良性变化导致糖原含量增加、脂质水平降低和生物能过程增强。
