Nepomniashchikh G I, Efremov V N, Nepomniashchikh L M, Tumanov V P
Biull Eksp Biol Med. 1985 Dec;100(12):744-8.
Synthesis of DNA, RNA and protein in the structures of large bronchi in patients with chronic inflammatory processes was studied. It was shown, that nuclei of all cell types of the tegmental bronchial epithelium, capillary endotheliocytes and stromal cells actively included 3H-uridine. By the intensification of bronchial wall sclerosis index and hardness of label with 3H-uridine were reduced in epitheliocytes, endotheliocytes, pericytes, labrocytes, macrophages, but were increased in fibroblasts which also had a high level of 3H-proline inclusion. High index of label with 3H-thymidine was found in basal cells of epithelium and capillary endotheliocytes. In conditions of chronic inflammation of bronchial wall the greatest metabolic and proliferative activity was found in the capillary endotheliocytes and cells of a pericapillary zone. In sclerosis the proliferative activity of basal cells was changed, that predetermined the character of tegmental epithelium reorganization.
研究了慢性炎症过程患者大支气管结构中DNA、RNA和蛋白质的合成。结果表明，被覆支气管上皮、毛细血管内皮细胞和基质细胞的所有细胞类型的细胞核均活跃摄取3H-尿苷。随着支气管壁硬化指数的增加，上皮细胞、内皮细胞、周细胞、淋巴细胞、巨噬细胞中3H-尿苷的标记强度降低，但成纤维细胞中3H-尿苷的标记强度增加，且成纤维细胞中3H-脯氨酸的摄取水平也较高。上皮基底细胞和毛细血管内皮细胞中发现3H-胸腺嘧啶核苷的高标记指数。在支气管壁慢性炎症情况下，毛细血管内皮细胞和毛细血管周围区域的细胞具有最大的代谢和增殖活性。在硬化过程中，基底细胞的增殖活性发生改变，这决定了被覆上皮重组的特征。
