Polosukhin V V, Egunova S M, Chuvakin S G, Bessonov A P
Thoracic Laser Center, Novosibirsk, Russia.
Arkh Patol. 1995 Nov-Dec;57(6):26-31.
Structural metabolic changes in the biopsies of the large bronchi mucous membrane were studied in 99 patients with chronic lung diseases. Progressing sclerosis of the connective tissue stroma resulted in the reduction of endotheliocyte metabolism which usually represent plastically active zone of the strom. This considerably influences basal cell proliferation resulting in changes of differentiation in bronchial epithelium. Endobronchial laser therapy induces proliferative and metabolic processes in the tunica propria of the mucous membrane. Congestion, intensive leucodia pedesis, leucocytic infiltrates and granulations develop in the mucous membrane, proliferative and metabolic activity of endotheliocytes and stromal cells increases this resulting in formation of fine fibrillar connective tissue.
对99例慢性肺部疾病患者的大支气管黏膜活检组织中的结构代谢变化进行了研究。结缔组织基质的进行性硬化导致内皮细胞代谢减少,而内皮细胞代谢通常代表基质的可塑性活跃区域。这对基底细胞增殖有相当大的影响,导致支气管上皮细胞分化发生变化。支气管内激光治疗可诱导黏膜固有层中的增殖和代谢过程。黏膜出现充血、大量白细胞游出、白细胞浸润和肉芽组织,内皮细胞和基质细胞的增殖及代谢活性增加,进而形成细纤维结缔组织。