Sidorova L D, Naumova L A, Nepomniashchikh G I
Ter Arkh. 1994;66(3):38-42.
A clinical-morphological study of bronchobiopsies from 78 patients with endoscopic picture of atrophic endobronchitis was carried out. Two forms of morphogenesis of chronic atrophic process in the bronchial mucosa are distinguished: primary dystrophic and primary inflammatory. Primary dystrophic bronchopathy is a clinical manifestations of the first form which presents structurally and functionally as primary dystrophy and atrophy of the bronchial mucosa in combination with sclerosis of the lamina propria in a sharp decrease of synthetic processes in bronchial epitheliocytes as indicated by the data of autoradiography. The primary inflammatory form of atrophic process has clinical symptoms typical for inflammatory process and is characterized by gradual reorganization in the bronchial wall and by maintaining sufficiently high level of metabolic reactions in bronchial epitheliocytes.
对78例具有萎缩性细支气管炎内镜表现患者的支气管活检标本进行了临床形态学研究。支气管黏膜慢性萎缩性病变有两种形态发生形式:原发性营养不良型和原发性炎症型。原发性营养不良型支气管病是第一种形式的临床表现,从结构和功能上看,它表现为支气管黏膜的原发性营养不良和萎缩,伴有固有层硬化,放射自显影数据显示支气管上皮细胞的合成过程急剧减少。萎缩性病变的原发性炎症型具有炎症过程的典型临床症状,其特征是支气管壁逐渐重塑,支气管上皮细胞维持足够高的代谢反应水平。