Odhiambo Francesca, Mando Raphael Onyango, Lewis-Kulzer Jayne, Mocello A Rain, Aluda Maurice, Mulwa Edwin, Aoko Appolonia, Musingila Paul, Bukusi Elizabeth, Cohen Craig R
Centre for Microbiology Research, Research Care and Training Program, Kenya Medical Research Institute, Nairobi, Kenya.
Department of Obstetrics, Gynecology & Reproductive Sciences, University of California San Francisco, San Francisco, United States of America.
PLOS Glob Public Health. 2025 Aug 1;5(8):e0004481. doi: 10.1371/journal.pgph.0004481. eCollection 2025.
The adoption of the test and treat policy by the World Health Organization (WHO) in 2015 led to an unprecedented increase in the number of people living with HIV (PLHIV) enrolling into HIV treatment, thereby increasing the burden on HIV service delivery. To compensate, WHO endorsed the Differentiated Service Delivery (DSD) approach to reduce the burden on the health care system and therefore support attainment of the UNAIDS 95-95-95 goals by 2030. This study examined clinical outcomes among clients enrolled in the DSD models and examined health care worker and client experiences of the DSD approach. A client-level pre-post study was conducted in 14 Ministry of Health (MOH) facilities in Kisumu County from October 2014 - March 2021 to examine retention and viral load suppression (<1000 copies/mL) in a cohort of stable clients aged 20 years and above at three time points: immediately preceding DSD start (pre-DSD; 2014-2016), 12 months post-DSD implementation (midline), and 24 months post-DSD (endline). Focus group discussions (FGDs) were conducted to assess DSD experiences among a sample of adult clients and health care workers. Findings from the pre-post analysis showed a significant increase in retention at 12 months (99.2%) and 24 months (98.9%) compared to pre-DSD (86.4%; p < 0.001). The predominant themes shared by clients and healthcare workers in FGDs were high satisfaction with DSD due to the efficiency of services, improved staff attitudes, and reduced clinic workload. Clients also expressed a strong preference for facility-based models owing to perceived stigma and privacy concerns associated with community DSD models. This study provides important insights on the promising effectiveness of DSD models on sustained retention on ART and viral suppression and the acceptability of this modality for client-centered HIV care.
2015年世界卫生组织(WHO)采用的检测与治疗政策导致感染艾滋病毒者(PLHIV)接受艾滋病毒治疗的人数空前增加,从而加重了艾滋病毒服务提供的负担。为了应对这一情况,世卫组织批准了差异化服务提供(DSD)方法,以减轻医疗系统的负担,从而支持到2030年实现联合国艾滋病规划署的95-95-95目标。本研究调查了参与DSD模式的客户的临床结果,并考察了医护人员和客户对DSD方法的体验。2014年10月至2021年3月,在基苏木县的14个卫生部(MOH)设施中开展了一项客户层面的前后对照研究,以考察20岁及以上稳定客户群体在三个时间点的留存率和病毒载量抑制情况(<1000拷贝/毫升):DSD开始前(DSD前;2014-2016年)、DSD实施后12个月(中期)和DSD实施后24个月(末期)。开展了焦点小组讨论(FGD),以评估成年客户和医护人员样本对DSD的体验。前后对照分析的结果显示,与DSD前(86.4%;p<0.001)相比,12个月(99.2%)和24个月(98.9%)的留存率显著提高。在焦点小组讨论中,客户和医护人员共同提到的主要主题是,由于服务效率高、工作人员态度改善以及诊所工作量减少,对DSD非常满意。由于感觉到与社区DSD模式相关的耻辱感和隐私问题,客户还表示强烈倾向于基于设施的模式。本研究为DSD模式在抗逆转录病毒治疗的持续留存和病毒抑制方面的显著有效性以及这种模式在以客户为中心的艾滋病毒护理中的可接受性提供了重要见解。