Niu Yongling, Fan Ziyi, Wang Zelin, Liang Shufen
Department of Neurology, The Second Hospital of Shanxi Medical University, Taiyuan, China.
Department of Oncology, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, China.
PLoS One. 2025 Aug 1;20(8):e0329540. doi: 10.1371/journal.pone.0329540. eCollection 2025.
As we all known oxidative stress and inflammation were interdependent and interconnected. Oxidative balance score (OBS) could assess the antioxidant capacity of an individual's body. The purpose of this study sought to investigate the connection between OBS and the recently proposed inflammatory indicator--Systemic immune-inflammation index (SII).
The study incorporated 16,080 participants from National Health and Nutrition Examination Survey (NHANES) database (2003-2018). We utilized weight multivariable linear regression analyses to assess this association. Additionally, subgroup analyses and linear relationships were performed for deeper insights. The robustness of the findings was ensured by conducting multiple sensitivity analyses.
In the multivariate model using the first OBS category as the reference, higher OBS quartiles had a significantly negative association with SII [β = -51.52 (95%CI: -68.31, -34.73), P for trend < 0.001]. The interaction test showed that age (P < 0.001) and hypertension (P = 0.043) had a significant effect on this connection. Restricted cubic splines plot with four knots illustrated a linear relationship between OBS and SII (P-non-liner = 0.677). The findings from the sensitivity analysis aligned with the outcomes of the primary analysis, confirming the consistency and reliability of the results.
OBS based on diet and lifestyle had a strongly negative association with SII. This study emphasized the importance of improving an individual's overall antioxidant status through diet and lifestyle changes, highlighting its effectiveness in reducing inflammation index.
众所周知，氧化应激和炎症相互依存、相互关联。氧化平衡评分（OBS）可评估个体身体的抗氧化能力。本研究旨在探讨OBS与最近提出的炎症指标——全身免疫炎症指数（SII）之间的联系。
该研究纳入了来自国家健康与营养检查调查（NHANES）数据库（2003 - 2018年）的16,080名参与者。我们采用加权多变量线性回归分析来评估这种关联。此外，还进行了亚组分析和线性关系分析以获得更深入的见解。通过进行多次敏感性分析确保了研究结果的稳健性。
在以第一OBS类别为参照的多变量模型中，较高的OBS四分位数与SII呈显著负相关[β = -51.52（95%CI：-68.31，-34.73），趋势P < 0.001]。交互作用检验表明年龄（P < 0.001）和高血压（P = 0.043）对这种关联有显著影响。具有四个节点的受限立方样条图说明了OBS与SII之间的线性关系（P - 非线性 = 0.677）。敏感性分析的结果与主要分析的结果一致，证实了结果的一致性和可靠性。
基于饮食和生活方式的OBS与SII呈强烈负相关。本研究强调了通过饮食和生活方式改变来改善个体整体抗氧化状态的重要性，突出了其在降低炎症指数方面的有效性。
