Shao Qingqing, Liu Tong, Hu Bin, Chen Liuqing
Department of Dermatology, Wuhan No. 1 Hospital, Wuhan, China; Department of Dermatology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Dermatology, Wuhan No. 1 Hospital, Wuhan, China; Hubei Province & Key Laboratory of Skin Infection and Immunity, Wuhan, China.
Virus Res. 2025 Jul 30;359:199611. doi: 10.1016/j.virusres.2025.199611.
Autophagy and apoptosis are two pivotal programmed cell death pathways that regulate vital physiological processes, ranging from cellular development to intracellular homeostasis. These pathways also act as key battlegrounds in host-pathogen interactions during viral infection. This comprehensive review explores the dual regulatory mechanisms controlling autophagy and apoptosis triggered by clinically significant human viruses. These include DNA viruses-such as herpes simplex virus (HSV), Epstein-Barr virus (EBV), hepatitis viruses, human papillomavirus (HPV), and human bocavirus (HBoV)-and RNA viruses, including human immunodeficiency virus type 1 (HIV-1), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), enterovirus 71 (EV71), influenza viruses, respiratory syncytial virus (RSV), Coxsackievirus B (CVB), rabies virus (RABV), and dengue virus serotype 2 (DENV2). We specifically highlight the dynamic crosstalk between autophagic and apoptotic pathways during viral pathogenesis, analyzing how viruses strategically co-opt both cellular processes to facilitate infection. By systematically elucidating these viral manipulation strategies, this review aims to provide a reference for developing targeted antiviral strategies and identifying novel therapeutic interventions.
自噬和凋亡是两种关键的程序性细胞死亡途径，它们调节着从细胞发育到细胞内稳态等重要的生理过程。在病毒感染期间，这些途径也是宿主与病原体相互作用的关键战场。这篇综述探讨了由临床上重要的人类病毒引发的自噬和凋亡的双重调控机制。这些病毒包括DNA病毒，如单纯疱疹病毒（HSV）、爱泼斯坦-巴尔病毒（EBV）、肝炎病毒、人乳头瘤病毒（HPV）和人博卡病毒（HBoV），以及RNA病毒，包括1型人类免疫缺陷病毒（HIV-1）、严重急性呼吸综合征冠状病毒2（SARS-CoV-2）、肠道病毒71型（EV71）、流感病毒、呼吸道合胞病毒（RSV）、柯萨奇病毒B（CVB）、狂犬病病毒（RABV）和登革热病毒2型（DENV2）。我们特别强调了病毒发病机制中自噬和凋亡途径之间的动态相互作用，分析了病毒如何策略性地利用这两种细胞过程来促进感染。通过系统地阐明这些病毒操纵策略，本综述旨在为制定针对性的抗病毒策略和确定新的治疗干预措施提供参考。
