Xu Jianjie, Han Zhuo Rachel, Lv Xiangxi, Chen Lu, Mao Ningning, Gao Mengyu Miranda, Zhang Hanyi, Hu Yueqin, Qin Shaozheng, Gross James J, Zhang Zhanjun
Beijing Key Laboratory of Applied Experimental Psychology, National Demonstration Center for Experimental Psychology Education, National Virtual Simulation Center for Experimental Psychology Education, Faculty of Psychology, Beijing Normal University, Beijing, China.
Faculty of Psychology, Beijing Normal University, Beijing, China.
NPJ Digit Med. 2025 Aug 1;8(1):491. doi: 10.1038/s41746-025-01888-5.
Depressive symptoms pose a serious global threat to well-being, highlighting the need for scalable mental health interventions. E-mental health interventions offer promising population-level solutions, yet few are grounded in theory or tested on large samples. This study utilizes an innovative e-mental health intervention based on the Extended Process Model of Emotion Regulation and examines the effectiveness of this theory-based intervention across a randomized controlled trial (RCT, N = 187; Chinese Clinical Trial Registry: ChiCTR2400081964; registration date: March 18th, 2024) and two extensive real-world studies (N = 11,554, N = 44,018) conducted with adults in China. The RCT confirmed the efficacy of this intervention, and both of the real-world e-mental health intervention studies showed a decrease in depressive symptoms (35-36%) and an increase in well-being (14-16%) over 21 days. These findings highlight the potential of theory-based e-mental health interventions as scalable solutions for early depression intervention and prevention, offering substantial societal and economic advantages.
抑郁症状对全球幸福感构成严重威胁，凸显了可扩展心理健康干预措施的必要性。电子心理健康干预措施提供了有前景的针对人群的解决方案，但很少有基于理论或在大样本上进行测试的。本研究采用了一种基于情绪调节扩展过程模型的创新电子心理健康干预措施，并在一项随机对照试验（RCT，N = 187；中国临床试验注册中心：ChiCTR2400081964；注册日期：2024年3月18日）以及两项针对中国成年人开展的大规模真实世界研究（N = 11,554，N = 44,018）中检验了这种基于理论的干预措施的有效性。随机对照试验证实了该干预措施的疗效，两项真实世界电子心理健康干预研究均显示，在21天内抑郁症状有所减轻（35 - 36%），幸福感有所提升（14 - 16%）。这些发现凸显了基于理论的电子心理健康干预措施作为早期抑郁干预和预防的可扩展解决方案的潜力，具有显著的社会和经济优势。
