Buldukoglu Osman Cagin, Ocal Serkan, Akca Serdar, Atar Galip Egemen, Harmandar Ferda Akbay, Cekin Ayhan Hilmi
Department of Gastroenterology, Antalya Training and Research Hospital, University of Health Sciences, Varlik mah. Kazim Karabekir cad, Antalya, 07100, Turkey.
BMC Gastroenterol. 2025 Aug 1;25(1):548. doi: 10.1186/s12876-025-04172-8.
Diverticulosis is the most common benign pathology of the colon. Genetics, inflammation, neuromuscular abnormalities, colonic motility and lifestyle including dietary habits play roles in disease pathogenesis. Coffee is one of the most commonly consumed beverages worldwide and exerts antiinflammatory functions in the human body as well as affecting colonic motility and neuromuscular physiology of the gastrointestinal system. Therefore, this study was planned to investigate the relationship between coffee consumption and diverticulosis.
A total of 1669 patients undergoing colonoscopy was enrolled in this cross-sectional study over a span of one year. Data from the patients was gathered through a questionnaire and matched with colonoscopy results. Coffee consumption was evaluated both as total cups of coffee consumed regardless of subtype per day and individual consumption of subtypes which were designated as instant coffee (Nescafe), Turkish coffee and brewed coffee (referred to as machine coffee in Turkey).
Overall coffee consumption regardless of subtype was not found to be related to diverticulosis. Multivariate logistic regression analysis revealed age and non-steroid antiinflammatory drug usage were risk factors for diverticulosis with odds ratios of 1.062 and 1.645 respectively. Regular exercise was found to be related with lower rates of colonic diverticulosis with an odds ratio of 0.684. Coffee consumption be it total sum or specific subtypes or caffeine intake were not found to be statistically significantly related to diverticulosis in multivariate logistic regression analysis.
This study revealed that coffee intake or caffeine intake does not increase the risk of colonic diverticulosis. Further research may explore whether different coffee types have varying effects.
憩室病是结肠最常见的良性病变。遗传、炎症、神经肌肉异常、结肠动力以及包括饮食习惯在内的生活方式在疾病发病机制中起作用。咖啡是全球最常饮用的饮品之一，在人体中发挥抗炎作用，同时影响胃肠道的结肠动力和神经肌肉生理。因此，本研究旨在调查咖啡饮用与憩室病之间的关系。
在一年时间内，共有1669例接受结肠镜检查的患者纳入本横断面研究。通过问卷调查收集患者数据，并与结肠镜检查结果进行匹配。咖啡饮用情况既评估为每天饮用的咖啡总杯数（不考虑亚型），也评估为各亚型的个体饮用量，这些亚型被指定为速溶咖啡（雀巢咖啡）、土耳其咖啡和煮制咖啡（在土耳其称为机器咖啡）。
总体而言，无论咖啡亚型，其饮用与憩室病无关。多因素逻辑回归分析显示，年龄和使用非甾体抗炎药是憩室病的危险因素，优势比分别为1.062和1.645。发现规律运动与较低的结肠憩室病发生率相关，优势比为0.684。在多因素逻辑回归分析中，咖啡饮用总量、特定亚型或咖啡因摄入量均未发现与憩室病有统计学显著相关性。
本研究表明，摄入咖啡或咖啡因不会增加结肠憩室病的风险。进一步的研究可以探索不同类型的咖啡是否有不同的影响。
