Su Gongmeiyue, Liu Yangkun, Chou Wenxin, Xiao Yilei, Li Zhao, Dai Rongji, Deng Yulin, Zhao Hongyou
School of Medical Technology, Beijing Institute of Technology, 5 South Zhongguancun Street, Haidian District, Beijing, 100081, China; Beijing Key Laboratory for Separation and Analysis in Biomedicine and Pharmaceuticals, Institute of Engineering Medicine, Beijing Institute of Technology, 5 South Zhongguancun Street, Haidian District, Beijing, 100081, China.
School of Medical Technology, Beijing Institute of Technology, 5 South Zhongguancun Street, Haidian District, Beijing, 100081, China.
Eur J Med Chem. 2025 Nov 15;298:118016. doi: 10.1016/j.ejmech.2025.118016. Epub 2025 Jul 30.
The development of wound dressings with high antibacterial efficacy is critical for the treatment of bacterial infections. Antimicrobial photodynamic therapy (aPDT) is a promising approach, and aggregation-induced emission photosensitizers (AIE-PSs) have garnered significant attention for their enhanced performance in the aggregated state, where the restriction of intramolecular motion serves as the underlying mechanism. However, conventional aggregation often leads to loosely packed PSs, leaving space for intramolecular motion. Crystallization provides a powerful strategy for forming tightly packed molecular aggregates. In this study, an AIE-PS (MeTSIC) was designed by attaching a propeller-like moiety to rigid planar groups. The former enables intramolecular motion and maintains a twisted conformation, while the latter facilitates crystallization. A bactericidal function alone is insufficient for optimal wound healing; thus, a hydrogel matrix was introduced for biocompatibility. The AIE-PS can easily form microcrystals (MCs) when its concentrated solution is added to the pre-gel solution. Subsequent photo-crosslinking in situ forms the light-activated antibacterial AIE-PS-MCs@hydrogel dressing on the wound. Under white light irradiation, the dressing effectively eliminates bacteria, reduces inflammation, promotes vascular network recovery, and accelerates wound healing. The combination of AIE-PS MCs with hydrogel offers a simple, effective strategy for managing infected wounds, with promising potential for future clinical applications.
开发具有高抗菌功效的伤口敷料对于治疗细菌感染至关重要。抗菌光动力疗法（aPDT）是一种很有前景的方法，聚集诱导发光光敏剂（AIE-PSs）因其在聚集状态下的增强性能而备受关注，分子内运动受限是其潜在机制。然而，传统的聚集通常会导致PSs堆积松散，为分子内运动留下空间。结晶为形成紧密堆积的分子聚集体提供了一种有力策略。在本研究中，通过将螺旋桨状部分连接到刚性平面基团上设计了一种AIE-PS（MeTSIC）。前者能够实现分子内运动并保持扭曲构象，而后者则有助于结晶。仅具有杀菌功能不足以实现最佳伤口愈合；因此，引入水凝胶基质以实现生物相容性。当将AIE-PS的浓溶液加入到预凝胶溶液中时，它很容易形成微晶（MCs）。随后的原位光交联在伤口上形成光激活抗菌的AIE-PS-MCs@水凝胶敷料。在白光照射下，该敷料能有效消除细菌、减轻炎症、促进血管网络恢复并加速伤口愈合。AIE-PS微晶与水凝胶的结合为处理感染伤口提供了一种简单有效的策略，具有广阔的未来临床应用潜力。
