Ma Yu, You Jiawei, Hou Jianquan, Shi Yupeng, Zhao Engui
School of Biomedical Engineering and Digital Health, School of Science, Harbin Institute of Technology (Shenzhen), Shenzhen, Guangdong, 518055, China.
Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
J Mater Chem B. 2025 Jan 22;13(4):1326-1337. doi: 10.1039/d4tb02372b.
Photodynamic antimicrobial therapy (aPDT) can effectively kill bacteria without promoting drug resistance. However, the phototoxicity of photosensitizers in aPDT against normal cells hinders their practical applications. In this work, we report the utilization of an aggregation-induced emission (AIE)-active photosensitizer, DTTPB, to develop antibacterial dressing for effective eradication of both Gram-positive and Gram-negative bacteria. The D-π-A structure of DTTPB facilitates efficient ROS generation in the aggregate state, addressing the limitations of a traditional photosensitizer. Notably, DTTPB demonstrates good biocompatibility towards normal cells, which minimizes its phototoxicity to normal tissues. To demonstrate its practical implications, DTTPB is combined with Carbomer 940 to create an injectable hydrogel dressing (DTTPB@gel). DTTPB@gel not only adheres to wounds but also maintains the antimicrobial properties of DTTPB, which together contributes to its enhanced wound-healing performance. Biocompatibility and toxicity assessments confirm the safety of this novel material, highlighting its potential as a practical and effective treatment for bacterial infections in wounds. The results underscore the importance of innovative antimicrobial strategies in fighting against antibiotic resistance, paving the way for safer and more effective therapeutic options.
光动力抗菌疗法（aPDT）可以有效杀灭细菌而不促进耐药性。然而，aPDT中光敏剂对正常细胞的光毒性阻碍了它们的实际应用。在这项工作中，我们报道了利用一种聚集诱导发光（AIE）活性光敏剂DTTPB来开发抗菌敷料，以有效根除革兰氏阳性菌和革兰氏阴性菌。DTTPB的D-π-A结构有助于在聚集状态下高效产生活性氧，解决了传统光敏剂的局限性。值得注意的是，DTTPB对正常细胞表现出良好的生物相容性，从而将其对正常组织的光毒性降至最低。为了证明其实际应用价值，将DTTPB与卡波姆940结合制备了一种可注射水凝胶敷料（DTTPB@凝胶）。DTTPB@凝胶不仅能粘附在伤口上，还能保持DTTPB的抗菌性能，这共同促进了其增强的伤口愈合性能。生物相容性和毒性评估证实了这种新型材料的安全性，突出了其作为伤口细菌感染实用有效治疗方法的潜力。这些结果强调了创新抗菌策略在对抗抗生素耐药性方面的重要性，为更安全、更有效的治疗选择铺平了道路。
