Blakley B R, Hamilton D L
Can J Comp Med. 1985 Oct;49(4):405-8.
The relationship between ceruloplasmin, a metalloenzyme with oxidase activity, and copper was investigated in cattle and sheep. The oxidase activity of ceruloplasmin correlated closely with the serum or plasma copper concentrations in cattle. The respective correlation coefficients were 0.83 and 0.60. In sheep serum, a correlation coefficient of 0.92 was obtained. In each instance, the relationship remained linear from the deficient to the high normal ranges of copper. Comparison of the linear regression relationships indicated the ceruloplasmin activity in bovine serum was statistically lower than the activity in bovine plasma (P less than 0.0001), through the intercepts from the regression lines of the two relationships were similar (P = 0.412). Comparisons of ovine and bovine serum-ceruloplasmin relationships indicated that a significant species difference was present. Ovine ceruloplasmin activity increased more rapidly as compared to the corresponding bovine activity over the range of copper concentrations investigated (P less than 0.0001). The intercept from the ovine regression relationship was also lower (P less than 0.0001). A correlation coefficient of 0.35 was observed between the serum ceruloplasmin activity and hepatic copper concentrations in cattle indicating that the mathematical relationship was not as well defined. Ceruloplasmin activity appears to correlate more closely with serum or plasma copper concentrations as compared to corresponding liver copper concentrations.
对牛和羊体内具有氧化酶活性的金属酶——铜蓝蛋白与铜之间的关系进行了研究。牛体内铜蓝蛋白的氧化酶活性与血清或血浆铜浓度密切相关。各自的相关系数分别为0.83和0.60。在绵羊血清中，相关系数为0.92。在每种情况下，从铜缺乏到高正常范围，这种关系均保持线性。线性回归关系的比较表明，牛血清中的铜蓝蛋白活性在统计学上低于牛血浆中的活性（P<0.0001），尽管两种关系的回归线截距相似（P = 0.412）。绵羊和牛血清 - 铜蓝蛋白关系的比较表明存在显著的物种差异。在所研究的铜浓度范围内，与相应的牛活性相比，绵羊铜蓝蛋白活性增加得更快（P<0.0001）。绵羊回归关系的截距也更低（P<0.0001）。在牛中，血清铜蓝蛋白活性与肝脏铜浓度之间的相关系数为0.35，这表明数学关系不太明确。与相应的肝脏铜浓度相比，铜蓝蛋白活性似乎与血清或血浆铜浓度的相关性更强。
