Shirai T, Masuda A, Fukushima S, Hosoda K, Ito N
Cancer Lett. 1985 Dec;29(3):283-8. doi: 10.1016/0304-3835(85)90138-7.
The modifying effects of 3 antioxidants, sodium L-ascorbate (SA), ascorbic acid (AA) and sodium erythorbate (SE) on two-stage gastric carcinogenesis in F344 rats initiated with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) were investigated. Administration of 5% SE in the diet significantly decreased the incidence of dysplasia of the pylorus and, more marginally the incidence of papilloma of the forestomach, whereas administration of 5% and 1% SA and 5% AA in the diet was not associated with effect. These results suggest that SE exerts a weak inhibitory effect on gastric carcinogenesis.
研究了3种抗氧化剂，即L-抗坏血酸钠（SA）、抗坏血酸（AA）和异抗坏血酸钠（SE）对用N-甲基-N'-硝基-N-亚硝基胍（MNNG）启动的F344大鼠两阶段胃癌发生的修饰作用。在饮食中给予5%的SE可显著降低幽门发育异常的发生率，对前胃乳头状瘤的发生率影响较小，而在饮食中给予5%和1%的SA以及5%的AA则无此作用。这些结果表明，SE对胃癌发生有微弱的抑制作用。
