Zhu Huanle, Qi Yuchen, Hua Shiyuan, Huang Rongrong, Chen Lumin, Zhou Xiaoxuan, He Jian, Hu Hongjie, Niu Zhongfeng
Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, Zhejiang, China.
Institute of Translational Medicine, Zhejiang University, Hangzhou, 310009, China.
Sci Rep. 2025 Aug 3;15(1):28298. doi: 10.1038/s41598-025-13072-6.
Inorganic nanoparticles play important roles in cancer treatment, but the issues of biodegradable properties, and tumor penetration restricted further clinical application. Aiming at the low efficiency and toxic side effects problems existing in the current clinical treatment of cancer, a biodegradable mesoporous silica nanoparticle (MSN) platform integrating pH-responsive drug release and synergistic chemo-radiotherapy was developed. The doxorubicin hydrochloride (DOX) was loaded in MSNs via electrostatic interactions, with ultra-small hafnium sulfide (HfS) nanodots were anchored to the surface of MSN. At physiological pH, HfS₂ reinforces DOX retention through steric and electrostatic effects, while in acidic tumor microenvironments, it triggers DOX release. Concurrently, dissociated HfS acts as a radiosensitizer, enhancing X-ray-induced cytotoxicity and promoting deep tumor penetration. Both the in vitro cellular and in vivo animal level results confirmed synergistically enhanced chemoradiotherapy efficiency. Therefore, this research, we believed, will bring a new train of thought and scientific support for more safety and more efficiency in cancer therapy.
无机纳米粒子在癌症治疗中发挥着重要作用，但生物可降解性能和肿瘤穿透性问题限制了其进一步的临床应用。针对当前癌症临床治疗中存在的低效和毒副作用问题，开发了一种集成pH响应药物释放和协同放化疗的可生物降解介孔二氧化硅纳米粒子（MSN）平台。盐酸阿霉素（DOX）通过静电相互作用负载于MSN中，超小硫化铪（HfS）纳米点锚定在MSN表面。在生理pH值下，HfS₂通过空间位阻和静电作用增强DOX的保留，而在酸性肿瘤微环境中，它触发DOX释放。同时，解离的HfS作为放射增敏剂，增强X射线诱导的细胞毒性并促进肿瘤深部渗透。体外细胞水平和体内动物水平的结果均证实了放化疗协同增效。因此，我们相信这项研究将为癌症治疗更安全、更高效带来新的思路和科学支持。
