Dykman Lev, Khlebtsov Boris, Khlebtsov Nikolai
Institute of Biochemistry and Physiology of Plants and Microorganisms, "Saratov Scientific Centre of the Russian Academy of Sciences", 13 Prospekt Entuziastov, Saratov 410049, Russia.
Institute of Biochemistry and Physiology of Plants and Microorganisms, "Saratov Scientific Centre of the Russian Academy of Sciences", 13 Prospekt Entuziastov, Saratov 410049, Russia; Saratov State University, 83 Ulitsa Astrakhanskaya, Saratov 410012, Russia.
Adv Drug Deliv Rev. 2025 Jan;216:115481. doi: 10.1016/j.addr.2024.115481. Epub 2024 Nov 29.
Modern nanotechnologies provide various possibilities for efficiently delivering drugs to biological targets. This review focuses on using functionalized gold nanoparticles (GNPs) as a drug delivery platform. Owing to their exceptional size and surface characteristics, GNPs are a perfect drug delivery vehicle for targeted and selective distribution. Several in vitro and in vivo tests have shown how simple it is to tailor these particles to administer chemical medications straight to tumors. The GNP surface can also be coated with ligands to modify drug release or improve selectivity. Moreover, the pharmacological activity can be enhanced by using the photothermal characteristics of the particles.
现代纳米技术为将药物高效递送至生物靶点提供了多种可能性。本综述聚焦于使用功能化金纳米颗粒（GNPs）作为药物递送平台。由于其独特的尺寸和表面特性，GNPs是用于靶向和选择性分布的理想药物递送载体。多项体外和体内试验表明，将这些颗粒进行定制以直接向肿瘤施用化学药物是多么简单。GNP表面还可以包覆配体以改变药物释放或提高选择性。此外，利用颗粒的光热特性可增强药理活性。
