Bush Larry M, Fiallo Priscila M, Vazquez-Pertejo Maria T
Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, USA.
Internal Medicine, Wellington Regional Medical Center, Wellington, USA.
Cureus. 2025 Jul 3;17(7):e87222. doi: 10.7759/cureus.87222. eCollection 2025 Jul.
SARS-CoV-2 (COVID-19) infection has been associated with various cutaneous manifestations presenting concomitantly with and following clinical resolution of active infection. Similarly, a variety of cutaneous conditions after mRNA-based COVID-19 vaccination, including specific local injection-site reactions, type I hypersensitivity, type IV (delayed) responses, and autoimmune-mediated reactions, has been observed. The commonality between natural infection and vaccination-related skin findings suggests a molecular mimicry of an immunologic nature. We present a case of a previously undescribed incident of cutaneous hyperpigmentation secondary to melanocyte dysfunction and melanin overproduction, triggered by an inflammatory event, in this case, immunization with an mRNA COVID-19 vaccine.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2，即新冠病毒）感染与各种皮肤表现有关，这些表现可在活动性感染的临床缓解期同时出现或在之后出现。同样，基于信使核糖核酸（mRNA）的新冠疫苗接种后也出现了多种皮肤状况，包括特定的局部注射部位反应、I型超敏反应、IV型（迟发型）反应以及自身免疫介导的反应。自然感染和疫苗接种相关皮肤表现之间的共性提示存在免疫性质的分子模拟。我们报告了一例此前未描述过的事件，即由炎症事件引发的黑素细胞功能障碍和黑色素过度产生导致的皮肤色素沉着，在本病例中，炎症事件为接种mRNA新冠疫苗。
