Lu Changpei, Zhang Rongshuang, Bi Lingbo, Luo Ting, Lai Wenbing, Fan Weixin, Jing Haixia
Department of Dermatology, Taihe Hospital, Hubei University of Medicine, Shiyan, People's Republic of China.
Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China.
Clin Cosmet Investig Dermatol. 2025 Jul 28;18:1801-1807. doi: 10.2147/CCID.S518408. eCollection 2025.
To conduct a retrospective review and analysis of clinical data on pilomatricoma over the past 9 years, with a focus on clinical characteristics, Diagnostic Challenges, and Therapeutic Outcomes.
We performed a retrospective study on patients diagnosed with pilomatricoma at our department from 2013 to 2022. Data collected from hospital and outpatient records, as well as pathological reports, included patient age, sex, onset, clinical and histopathological features, preoperative diagnosis, treatment methods, recurrence, and outcomes.
A total of 105 patients were included. The primary clinical manifestation was a slowly growing subcutaneous mass. The median age at excision was 14 years, with the youngest patient being 8 months old and the oldest 71 years old. Head and neck tumors accounted for 67.6% (n=71) of cases, followed by the upper limbs (20.9%, n=22), with other sites including the back and lower limbs. The male-to-female ratio was 1:1.6. Tumor diameter ranged from 0.4 to 5.0 cm, with a mean of 1.0 cm. Only one case exhibited recurrence. Differential diagnoses included epidermoid cyst, sebaceous cyst, and fibroma, among others. The characteristic histopathological features were eosinophilic ghost cells and basophilic basal-like cells arranged in irregular strands or clusters. The preoperative diagnosis was consistent with the pathological diagnosis in only 28 cases (26.7%). The optimal treatment approach is complete surgical excision, with a low recurrence rate of 1.0%. No cases of malignant transformation were observed.
Pilomatricoma is a benign tumor with atypical morphology, often leading to misdiagnosis. Careful histopathological examination is crucial, and early excision demonstrates significant effectiveness in preventing recurrence.
对过去9年里毛母质瘤的临床数据进行回顾性研究与分析，重点关注其临床特征、诊断挑战及治疗结果。
我们对2013年至2022年在我科诊断为毛母质瘤的患者进行了回顾性研究。从医院和门诊记录以及病理报告中收集的数据包括患者年龄、性别、发病情况、临床和组织病理学特征、术前诊断、治疗方法、复发情况及结果。
共纳入105例患者。主要临床表现为缓慢生长的皮下肿块。切除时的中位年龄为14岁，最年轻的患者为8个月大，最年长的为71岁。头颈部肿瘤占病例的67.6%（n = 71），其次是上肢（20.9%，n = 22），其他部位包括背部和下肢。男女比例为1:1.6。肿瘤直径范围为0.4至5.0厘米，平均为1.0厘米。仅1例出现复发。鉴别诊断包括表皮样囊肿、皮脂腺囊肿和纤维瘤等。特征性的组织病理学特征是嗜酸性影细胞和嗜碱性基底样细胞呈不规则条索状或团块状排列。术前诊断与病理诊断仅在28例（26.7%）中一致。最佳治疗方法是完整手术切除，复发率低至1.0%。未观察到恶变病例。
毛母质瘤是一种形态不典型的良性肿瘤，常导致误诊。仔细的组织病理学检查至关重要，早期切除在预防复发方面显示出显著效果。
