Ojanguren Iñigo, Alobid Isam, Rodríguez-Vázquez Virginia, Reyes Víctor, Espinosa Miriam, de Tena África Luca, Muerza Irantzu, Gómez de la Fuente Enrique
Pneumology Service, University Hospital Vall d'Hebron, VHIR, CIBERES, Autonomous University of Barcelona, Barcelona, Spain.
Rhinology and Skull Base Unit, Department of Otorhinolaryngology, Hospital Clínic, IDIBAPS, CPERES, Barcelona University, Barcelona, Spain.
Open Respir Arch. 2025 Jul 1;7(4):100461. doi: 10.1016/j.opresp.2025.100461. eCollection 2025 Oct-Dec.
Asthma is a heterogeneous disease that often coexists with type 2 inflammatory (T2i) conditions in many individuals with severe asthma, leading to heightened exacerbations that diminish their quality of life (QoL). Despite this, there is a noticeable scarcity of QoL assessment tools specifically designed for individuals with T2i-related asthma.
To analyse the asthma subset of T2i patients, derived from a survey conducted by the patient-driven T2i Network Project, aimed at identifying common drivers and challenges related to the QoL of T2i patients.
An anonymous online survey was distributed through eight Spanish patient associations. It comprised 29 questions about the patient's sociodemographic characteristics and several self-reported questions about the diagnosis, QoL measures, the severity of the disease, use of healthcare resources, and quality of care.
The T2i asthma sub-analysis included 180 participants; 93% self-reported their disease severity as moderate-to-severe, 85% affected by one or more coexisting T2i diseases. An increase in the self-perceived severity was associated with higher self-perceived intensity, lack of control, and persistence of symptoms, with a stronger impact on total QoL. Asthma participants expressed a great impact on all the measured dimensions of the QoL.
The results demonstrate unmet needs and important difficulties for asthma T2i patients, either as the only condition or with other T2i conditions, and underscore the need for innovative approaches to improve their QoL. Most of this subset of patients perceive their condition as severe and experience self-perceived intense and limiting symptoms, which constantly worsen and persist over time.
哮喘是一种异质性疾病，在许多重度哮喘患者中常与2型炎症（T2i）疾病共存，导致病情加重，降低了他们的生活质量（QoL）。尽管如此，专门为患有T2i相关哮喘的个体设计的生活质量评估工具却明显匮乏。
分析T2i患者的哮喘亚组，该亚组来自患者驱动的T2i网络项目进行的一项调查，旨在确定与T2i患者生活质量相关的常见驱动因素和挑战。
通过八个西班牙患者协会开展了一项匿名在线调查。调查包含29个关于患者社会人口学特征的问题，以及几个关于诊断、生活质量测量、疾病严重程度、医疗资源使用和护理质量的自我报告问题。
T2i哮喘亚分析纳入了180名参与者；93%的参与者自我报告其疾病严重程度为中度至重度，85%的参与者受到一种或多种共存的T2i疾病影响。自我感知严重程度的增加与更高的自我感知强度、缺乏控制和症状持续存在相关，对总体生活质量的影响更大。哮喘参与者表示对生活质量的所有测量维度都有很大影响。
结果表明，无论是作为单一疾病还是与其他T2i疾病并存，T2i哮喘患者都存在未满足的需求和重大困难，并强调需要创新方法来改善他们的生活质量。这一亚组中的大多数患者认为自己的病情严重，经历自我感知强烈且受限的症状，这些症状会不断恶化并随着时间持续存在。
