Kwong M B, Tong T K, Mickell J J, Chan J C
Clin Nephrol. 1985 Dec;24(6):285-8.
During the four-year period from January 1980 to April 1984, 56 patients were admitted to the Pediatric Intensive Care Unit (PICU) whose care required timed urine collections using indwelling urinary catheters. The glomerular filtration rate derived from the clearance of endogenous creatinine with accurate timed urine volume is compared to that derived from the formula, 0.55 body length (cm)/plasma creatinine (mg/dl). There is a significant difference in the results between the two methods, p less than 0.0001. The largest divergence arises in those with creatinine clearance of less than 40 ml/min per 1.73 sq.m. In this subgroup, the formula derived glomerular filtration rates consistently overestimate the renal function and create a misleading assurance of minimal renal impairment. Therefore, our findings suggest that the latter formula is not applicable to PICU patients for consideration of fluid and electrolyte balance, administration of nephrotoxic drugs or criteria for dialysis.
在1980年1月至1984年4月的四年期间，56名患儿被收治入儿科重症监护病房（PICU），对其进行护理时需要使用留置尿管定时收集尿液。将通过准确测量定时尿量并计算内生肌酐清除率得出的肾小球滤过率，与通过公式[0.55×身长（厘米）/血肌酐（毫克/分升）]得出的肾小球滤过率进行比较。两种方法的结果存在显著差异，P值小于0.0001。最大的差异出现在肌酐清除率低于每1.73平方米每分钟40毫升的患者中。在这个亚组中，通过公式得出的肾小球滤过率始终高估肾功能，并给人造成肾功能损害最小的误导性保证。因此，我们的研究结果表明，后一种公式不适用于PICU患者以考虑液体和电解质平衡、使用肾毒性药物或作为透析标准。
