Mitchell Sian, Bailey Frances, Smith Alison, Gaughran Jonathan, Holland Tom, Muallem Mustafa Zelal, Sayasneh Ahmad
Department of Women's Health, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Department of Gynecology with Center for Oncological Surgery, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Ultrasound. 2025 Jul 31:1742271X251353712. doi: 10.1177/1742271X251353712.
BACKGROUND & OBJECTIVES: The ultrasound features of ovarian mature teratomas are well defined. However, literature regarding the ultrasound features of immature teratomas is lacking and features can often be confused with those of mature teratomas. The objective of this study was to evaluate the subjective assessment of ultrasound examiners of anonymised static B mode ultrasound images of immature and mature teratomas.
An electronic questionnaire was distributed to levels 1 to 3 ultrasound examiners containing 23 anonymised ultrasound images including nine different immature teratomas and nine different mature teratomas. The images were collected retrospectively, and the reference test was the final histology of the surgically removed masses. The sensitivity and specificity test of the subjective assessment for each histological group was calculated. The live (at the time the scan was performed) subjective impression of each tumour was also recorded and the level of the examiner that performed the scan was noted.
There were a total of 43 responses (30 from level 1, 9 from level 2 and 4 from level 3 examiners. The sensitivity and specificity of subjective assessment ranged from 16.3% to 97.7% and 81.6% to 96.1%, respectively, for all histological groups. The sensitivity and specificity to correctly diagnose mature teratomas and immature teratomas were 41.3% (95% CI: 36.3%-46.4%), 82.2% (95% CI: 78.9%-85.1%) and 41.2 % (95% CI: 36.2%-46.3%), 81.6 % (95% CI: 78.3%-84.7%), respectively. There was no statistical difference in the diagnostic performance of the subjective assessment of examiners between mature and immature teratomas ( = 0.975).
Diagnostic performance of static 2D ultrasound images for mature and immature teratomas is low. Immature teratoma still pose a diagnostic challenge.
卵巢成熟畸胎瘤的超声特征已明确。然而，关于未成熟畸胎瘤超声特征的文献较少，其特征常与成熟畸胎瘤混淆。本研究旨在评估超声检查者对未成熟和成熟畸胎瘤匿名静态B模式超声图像的主观评估。
向1至3级超声检查者发放电子问卷，其中包含23张匿名超声图像，包括9种不同的未成熟畸胎瘤和9种不同的成熟畸胎瘤。图像为回顾性收集，参考标准为手术切除肿块的最终组织学检查结果。计算各组织学组主观评估的敏感性和特异性。记录每个肿瘤当时（扫描时）的主观印象，并注明进行扫描的检查者级别。
共收到43份回复（1级检查者30份，2级检查者9份，3级检查者4份）。所有组织学组主观评估的敏感性和特异性分别为16.3%至97.7%和81.6%至96.1%。正确诊断成熟畸胎瘤和未成熟畸胎瘤的敏感性和特异性分别为41.3%（95%CI：36.3%-46.4%）、82.2%（95%CI：78.9%-85.1%）和41.2%（95%CI：36.2%-46.3%）、81.6%（95%CI：78.3%-84.7%）。成熟和未成熟畸胎瘤检查者主观评估的诊断性能无统计学差异（=0.975）。
静态二维超声图像对成熟和未成熟畸胎瘤的诊断性能较低。未成熟畸胎瘤仍具有诊断挑战性。
