Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada.
Gynecol Oncol. 2011 Oct;123(1):50-3. doi: 10.1016/j.ygyno.2011.06.037. Epub 2011 Jul 20.
The aim of this study was to evaluate clinicopathologic characteristics, treatment outcome and reproductive function in women diagnosed with ovarian immature teratoma.
Thirty-four women with ovarian immature teratoma stages IA to IIIA were identified and included in this study. Patients were treated at one institution; Princess Margaret Hospital, Toronto, Canada between 1970 and 2005.
The median age at diagnosis was 25.0 years (range: 9.8-60.2 years). Twenty seven (79%) presented with stage IA disease, 5 (15%) with stage IC, 1 (3%) with stage 2B, and 1 (3%) with stage IIIA disease. Thirteen (38%) of the tumors were found to be grade 1, 12 (35%) grade 2, and 9 (27%) grade 3. Initial management was surgical for all patients: 22 (65%) unilateral oophorectomy, 7 (20%) cystectomy only, and 5 (15%) bilateral oophorectomy (4 with hysterectomy). Fourteen (41.8%) patients received adjuvant therapy. The median follow up was 4.8 years (range 0.2-24.3 years). Four patients recurred (histological grade 2 or 3) within 22 months (87.1% 2-year progression free survival). Only one clinical stage I patient who received adjuvant chemotherapy developed a recurrence. Three of the patients who recurred died from their disease. Eleven patients reported an attempt to conceive resulting in 11 pregnancies in 6 women (3 post chemotherapy).
The majority of patients diagnosed with an immature teratoma are cured of their disease. However, grade 2 or 3 tumors are associated with a greater chance of recurrence that can be fatal, predominantly within 2 years of diagnosis.
本研究旨在评估诊断为卵巢未成熟畸胎瘤的患者的临床病理特征、治疗结果和生殖功能。
本研究纳入了 34 名在加拿大安大略省多伦多玛格丽特公主医院于 1970 年至 2005 年期间诊断为卵巢未成熟畸胎瘤的患者。
患者中位诊断年龄为 25.0 岁（范围：9.8-60.2 岁）。27 名（79%）患者为 IA 期，5 名（15%）为 IC 期，1 名（3%）为 2B 期，1 名（3%）为 IIIA 期。13 名（38%）肿瘤为 1 级，12 名（35%）为 2 级，9 名（27%）为 3 级。所有患者均接受手术初始治疗：22 名（65%）行单侧卵巢切除术，7 名（20%）行单纯囊肿切除术，5 名（15%）行双侧卵巢切除术（4 例行子宫切除术）。14 名（41.8%）患者接受辅助治疗。中位随访时间为 4.8 年（范围 0.2-24.3 年）。4 名患者（组织学分级 2 级或 3 级）在 22 个月内复发（2 年无进展生存率为 87.1%）。仅 1 例临床 IA 期患者接受辅助化疗后复发。3 例复发患者因疾病死亡。11 名患者报告尝试怀孕，6 名女性（3 名化疗后）共怀孕 11 次。
大多数诊断为未成熟畸胎瘤的患者可治愈疾病。然而，2 级或 3 级肿瘤复发的可能性更高，且具有致命风险，主要发生在诊断后 2 年内。
