Hojo Kento, Abe Tomohiro, Tanaka Saki, Hatanaka Kengo, Ochiai Hidenobu
Department of Emergency and Critical Care Medicine University of Miyazaki Miyazaki Japan.
Department of Internal Medicine National Health Insurance Misato Town, Saigo Hospital Misato Miyazaki Japan.
Acute Med Surg. 2025 Aug 1;12(1):e70079. doi: 10.1002/ams2.70079. eCollection 2025 Jan-Dec.
The ingestion of glyphosate herbicides can cause severe acute kidney injury. We present a case of glyphosate poisoning in which creatinine levels were falsely elevated when measured using a dry chemistry analyzer.
An 83-year-old man ingested glyphosate herbicide during a suicide attempt and presented with gastrointestinal symptoms. A dry chemistry analyzer showed high creatinine levels (10.62 mg/dL); thus, the patient was transported to our hospital for renal replacement therapy. However, enzymatic testing showed a lower creatinine level (1.36 mg/dL). Further investigation comparing creatinine measurements revealed a high creatinine level only through the dry chemistry method, despite the relatively low glyphosate concentration (55 mg/L).
The dry chemistry method falsely shows an elevated creatinine value, which may affect clinical decisions regarding the management of patients with glyphosate poisoning. Careful interpretation of creatinine measurements using the dry chemistry method is important in glyphosate poisoning cases.
摄入草甘膦除草剂可导致严重的急性肾损伤。我们报告一例草甘膦中毒病例，该病例使用干式化学分析仪测量时肌酐水平出现假性升高。
一名83岁男性在自杀未遂时摄入了草甘膦除草剂，并出现胃肠道症状。干式化学分析仪显示肌酐水平较高（10.62mg/dL）；因此，该患者被转送至我院接受肾脏替代治疗。然而，酶法检测显示肌酐水平较低（1.36mg/dL）。进一步比较肌酐测量结果发现，尽管草甘膦浓度相对较低（55mg/L），但仅通过干式化学方法测得的肌酐水平较高。
干式化学方法错误地显示肌酐值升高，这可能会影响草甘膦中毒患者治疗的临床决策。在草甘膦中毒病例中，谨慎解读使用干式化学方法测得的肌酐值非常重要。
