Radafshar Mahsa, Parhizkar Ardavan
Department of Endodontics, Faculty of Dentistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Iranian Centre for Endodontic Research, Research Institute for Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Iran Endod J. 2025;20(1):e28. doi: 10.22037/iej.v20i1.48268. Epub 2025 Jul 19.
Geristore® (GS) is an advanced dual-cure resin-modified glass ionomer with favourable biological and physical properties, including biocompatibility, fluoride release, and excellent sealing ability. Originally developed for restorative purposes, its clinical versatility has nonetheless extended into endodontics. The current critical review primarily aims to evaluate the biological characteristics, endodontic applications, and possible clinical potential of GS as a biomaterial in modern endodontic practice.
A comprehensive literature search was conducted across major databases (MEDLINE, PubMed, Scopus, Cochrane, EMBASE, Google Scholar, and grey literature) without restrictions on date and/or language. Relevant peer-reviewed studies on the composition, properties, and endodontic uses of GS were identified, screened, investigated, and critically analysed.
Geristore® has demonstrated promising outcomes in endodontic procedures, ., root-end filling, perforation repair, vital pulp therapy, retrograde vital pulp therapy, intra-orifice barrier placement and the management of external cervical resorption, Additionally, various studies have highlighted its favourable soft tissue compatibility, sealing ability (even in moist environments) as well as its acceptable mechanical properties. However, certain limitations, including reduced flexural strength and higher cytotoxicity compared to calcium silicate-based materials, such as mineral trioxide aggregate, have been reported.
Geristore® presents as a clinically useful alternative for specific endodontic indications where biocompatibility, sealability, and ease of handling seem critical. However, further high-quality clinical trials and comparative studies are essential to validate its long-term performance and establish its role relative to established endodontic biomaterials.
Geristore®（GS）是一种先进的双重固化树脂改性玻璃离子水门汀，具有良好的生物学和物理性能，包括生物相容性、氟释放能力和出色的封闭能力。它最初是为修复目的而开发的，但临床应用范围已扩展到牙髓病学领域。本综述主要旨在评估GS作为现代牙髓病学实践中的生物材料的生物学特性、牙髓病学应用及潜在临床价值。
对主要数据库（MEDLINE、PubMed、Scopus、Cochrane、EMBASE、谷歌学术和灰色文献）进行全面的文献检索，检索日期和语言均无限制。对关于GS的成分、性能和牙髓病学用途的相关同行评审研究进行识别、筛选、调查和批判性分析。
Geristore®在牙髓病治疗中已显示出良好的效果，如根尖倒充填、穿孔修复、活髓治疗、逆行性活髓治疗、口内屏障放置以及外吸收的处理。此外，多项研究强调了其良好的软组织相容性、封闭能力（即使在潮湿环境中）以及可接受的机械性能。然而，也有报道称其存在某些局限性，如与矿物三氧化物凝聚体等硅酸钙基材料相比，弯曲强度较低且细胞毒性较高。
对于生物相容性、密封性和操作简便性似乎至关重要的特定牙髓病适应症，Geristore®是一种临床上有用的替代材料。然而，需要进一步开展高质量的临床试验和对比研究，以验证其长期性能，并确定其相对于现有牙髓病生物材料的作用。
