Smith R, Blum C, Benua R S, Fawwaz R A
Clin Nucl Med. 1985 Dec;10(12):874-5. doi: 10.1097/00003072-198512000-00011.
We present a case of well-differentiated follicular carcinoma of the thyroid with hyperfunctioning metastases and clinical thyrotoxicosis. The recommended I-131 treatment dose for patients with widespread bone metastases from thyroid carcinoma is 200 mCi. However, in a patient with hyperfunctioning metastatic tumor and increased radioiodine uptake, the treatment dose should be modified. Radiation dosimetry measurements performed on the patient in this study demonstrated that 132 mCi would be a safe therapeutic I-131 dose which would avoid injury to normal radiosensitive tissues. Consequently, she was given a 130-mCi therapeutic dose.
我们报告一例伴有功能亢进性转移灶及临床甲状腺毒症的高分化甲状腺滤泡癌病例。对于甲状腺癌广泛骨转移患者，推荐的碘-131治疗剂量为200毫居里。然而，对于有功能亢进性转移瘤且放射性碘摄取增加的患者，治疗剂量应进行调整。本研究中对该患者进行的放射剂量测定表明，132毫居里将是一个安全的碘-131治疗剂量，可避免对正常放射敏感组织造成损伤。因此，给她给予了130毫居里的治疗剂量。
