Saveliev Gabriel Marian, Varlas Valentin Nicolae, Piron-Dumitrascu Madalina, Suciu Nicolae
National Institute for Mother and Child Health Alessandrescu-Rusescu, Bucharest, Romania.
Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
J Med Life. 2025 Jun;18(6):590-593. doi: 10.25122/jml-2025-0100.
Cervical cancer (CC) remains a significant global health burden, ranking eighth in incidence and ninth in cancer-related mortality among women worldwide. Persistent infection with high-risk human papillomavirus (HPVhr) is the primary etiological factor in CC development. The SCCUT program in Romania was designed to enhance access to primary screening and assess HPVhr prevalence among women aged 25-65 years in the South-Muntenia region. Between August 2022 and November 2023, a total of 36,813 women were enrolled in the SCCUT program after providing informed consent. Based on age, participants underwent either a Pap test and/or HPVhr testing. Clinical and demographic data-including age, hormonal status, intrauterine device (IUD) use, presence of leucorrhea, and history of cervical interventions-were collected via structured questionnaires. HPVhr testing was performed using the AmpFire HPV Screening system and processed in the lead partner laboratory. Of the total cohort, 12.5% ( = 4,588) tested positive for HPVhr. HPVhr positivity was significantly associated with younger age (mean 45.12 ± 9.21 years vs. 46.28 ± 8.56 years; < 0.001) and cyclic hormonal status ( < 0.001). No statistically significant associations were found between HPVhr status and IUD use, presence of leucorrhea, or prior cervical interventions (biopsies or cauterizations). The SCCUT program confirms the critical role of HPVhr in cervical carcinogenesis and supports its use as a first-line screening tool. These findings highlight the importance of implementing widespread primary HPVhr testing, particularly in underserved populations. Increasing public awareness, improving HPV vaccination rates, and expanding access to early detection programs remain essential for effective cervical cancer prevention in Romania and globally.
宫颈癌（CC）仍然是一项重大的全球卫生负担，在全球女性癌症发病率中排名第八，在癌症相关死亡率中排名第九。高危型人乳头瘤病毒（HPVhr）的持续感染是宫颈癌发生的主要病因。罗马尼亚的SCCUT项目旨在增加初级筛查的可及性，并评估南蒙特尼亚地区25至65岁女性中HPVhr的流行情况。2022年8月至2023年11月期间，共有36813名女性在签署知情同意书后参加了SCCUT项目。根据年龄，参与者接受了巴氏试验和/或HPVhr检测。通过结构化问卷收集临床和人口统计学数据，包括年龄、激素状态、宫内节育器（IUD）使用情况、白带情况以及宫颈干预史。使用AmpFire HPV筛查系统进行HPVhr检测，并在牵头合作实验室进行处理。在整个队列中，12.5%（n = 4588）的人HPVhr检测呈阳性。HPVhr阳性与较年轻的年龄（平均45.12±9.21岁 vs. 46.28±8.56岁；P < 0.001）和周期性激素状态（P < 0.001）显著相关。未发现HPVhr状态与IUD使用、白带情况或先前的宫颈干预（活检或烧灼）之间存在统计学显著关联。SCCUT项目证实了HPVhr在宫颈癌发生中的关键作用，并支持将其用作一线筛查工具。这些发现凸显了开展广泛的初级HPVhr检测的重要性，尤其是在服务不足的人群中。提高公众意识、提高HPV疫苗接种率以及扩大早期检测项目的可及性，对于罗马尼亚乃至全球有效的宫颈癌预防仍然至关重要。
