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免疫功能正常患者的肺部伴肝脾播散:一例报告及文献复习

Pulmonary With Hepatosplenic Dissemination in an Immunocompetent Patient: A Case Report and Review.

作者信息

Wang Michael S, Chang Jeremiah, Whelan Tiffany, Liu Bo, Fitton Katie, Grondin Jeffrey J

机构信息

Department of Medicine, Corewell Health South - St. Joseph, MI, USA.

Osteopathic Medical Specialties, Michigan State University College of Osteopathic Medicine, East Lansing, MI, USA.

出版信息

J Community Hosp Intern Med Perspect. 2025 Jul 3;15(4):37-42. doi: 10.55729/2000-9666.1503. eCollection 2025.

DOI:10.55729/2000-9666.1503
PMID:40757233
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12315891/
Abstract

We report a 69-year-old with a past medical history of prostate cancer, and arsenic poisoning, who was incidentally found to have multiple pulmonary nodules and hepatosplenic lesions on CT imaging. He denied respiratory symptoms, but was noted to have significant weight loss. A bronchoscopy revealed on culture. He was treated presumptively for pulmonary and disseminated infection with azithromycin and ethambutol for 16 months, and 12 months of rifabutin after four months of rifampin which was discontinued due to resistance. Patient's weight loss resolved and CT imaging appeared significantly improved.

摘要

我们报告了一名69岁男性,有前列腺癌和砷中毒病史,CT成像偶然发现其有多个肺结节和肝脾病变。他否认有呼吸道症状,但体重明显减轻。支气管镜检查培养结果显示……。他接受了阿奇霉素和乙胺丁醇的经验性治疗,用于肺部和播散性感染,为期16个月,在利福平因耐药停用四个月后,接受了12个月的利福布汀治疗。患者体重减轻的情况得到缓解,CT成像显示明显改善。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a47d/12315891/fb8b60235117/jchim-15-04-037f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a47d/12315891/2a074886b89b/jchim-15-04-037f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a47d/12315891/fb8b60235117/jchim-15-04-037f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a47d/12315891/2a074886b89b/jchim-15-04-037f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a47d/12315891/fb8b60235117/jchim-15-04-037f2.jpg

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本文引用的文献

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A case report and literature review of nontuberculous mycobacterial disease caused by Mycolicibacterkumamotonensis.一株熊本分枝杆菌引起的非结核分枝杆菌病病例报告及文献综述
Indian J Med Microbiol. 2024 Nov-Dec;52:100731. doi: 10.1016/j.ijmmb.2024.100731. Epub 2024 Sep 12.
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A case of novel, rapidly-growing Mycolicibacter kumamotonensis infection in a patient with severe pulmonary disease treated in New York City.美国纽约市一例新型、快速生长分枝杆菌感染重症肺病患者。
BMC Infect Dis. 2023 Jan 13;23(1):26. doi: 10.1186/s12879-022-07959-2.
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复发性病情加重和哮喘控制不佳的一种罕见感染性病因 - 。
JRSM Open. 2022 Oct 13;13(10):20542704221124013. doi: 10.1177/20542704221124013. eCollection 2022 Oct.
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Hepatic tuberculosis masquerading as malignancy.肝结核伪装为恶性肿瘤。
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