Mulayamkuzhiyil Jiya, Joseph Justeena, Agrawal Anchita, Ojukwu Perdomo Tommy, Jain Sanjeev
NYU Langone Hospital-Suffolk, Patchogue, USA.
Jericho High School, Jericho, NY, USA.
J Investig Med High Impact Case Rep. 2025 Jan-Dec;13:23247096251363010. doi: 10.1177/23247096251363010. Epub 2025 Aug 4.
Small cell carcinoma of the esophagus is a rare and aggressive variant of esophageal cancer. We report a case of a 69-year-old female who presented with dysphagia to solid food for 6 months and underwent esophagogastroduodenoscopy, which revealed an ulcerated mass in the proximal esophagus. Biopsy findings were consistent with esophageal small cell cancer. The patient was found to have distant metastasis to the gastric lymph nodes on staging studies. She was treated with chemotherapy, resulting in initial disease resolution, but 4 years later, she presented with metastatic disease to the lungs and brain. This case underscores the need to establish treatment guidelines for this malignancy with a poor prognosis, given the paucity of randomized clinical trials.
食管小细胞癌是一种罕见且侵袭性强的食管癌变体。我们报告一例69岁女性患者，她出现固体食物吞咽困难6个月，接受了食管胃十二指肠镜检查，结果显示食管近端有一个溃疡肿块。活检结果与食管小细胞癌相符。分期检查发现该患者有胃淋巴结远处转移。她接受了化疗，最初病情得到缓解，但4年后，她出现了肺部和脑部转移。鉴于随机临床试验较少，该病例强调了为这种预后不良的恶性肿瘤制定治疗指南的必要性。
