Noe D A, Bell W R
Comput Biomed Res. 1985 Dec;18(6):544-52. doi: 10.1016/0010-4809(85)90029-1.
A model of red cell hemoglobin concentration has been developed and computer stimulations performed to investigate quantitatively the relationship among the intraindividual heterogeneities of cell hemoglobin content, volume, and hemoglobin concentration. In the model, the cell volume and hemoglobin content frequency distributions and their joint distributions are described by Gaussian probability distributions. The frequency distributions of cell hemoglobin concentration are determined from the joint probability distributions by summing the joint probabilities of the variate pairs the ratios of which equal the specified concentration. For the parameter values considered, the mean cell hemoglobin concentration closely approximates the average (i.e., statistical mean) concentration. The heterogeneity of cell hemoglobin concentration increases with increasing coefficients of variation of cell hemoglobin content and cell volume and with decreasing correlation coefficients. When the correlation coefficient is greater than 0.7, cell hemoglobin concentration shows less relative dispersion than the component indices.
已建立红细胞血红蛋白浓度模型并进行计算机模拟，以定量研究细胞血红蛋白含量、体积和血红蛋白浓度的个体内异质性之间的关系。在该模型中，细胞体积和血红蛋白含量的频率分布及其联合分布由高斯概率分布描述。细胞血红蛋白浓度的频率分布通过对变量对的联合概率求和来确定，这些变量对的比率等于指定浓度。对于所考虑的参数值，平均细胞血红蛋白浓度非常接近平均（即统计均值）浓度。细胞血红蛋白浓度的异质性随着细胞血红蛋白含量和细胞体积变异系数的增加以及相关系数的降低而增加。当相关系数大于0.7时，细胞血红蛋白浓度的相对离散度低于组成指数。
