Guo Yinghui, Wei Dongtao
School of Public Policy and Administration, Chongqing University, Chongqing, China.
Public Economic and Public Policy Research Center, Chongqing University, Chongqing, China.
PLoS One. 2025 Aug 4;20(8):e0328895. doi: 10.1371/journal.pone.0328895. eCollection 2025.
Task-based functional neuroimaging has revealed that rumination is associated with functional activations in the default mode network (DMN). The present study aimed to examine whether resting state functional connectivity (FC) within the DMN is associated with individual differences in trait rumination. Using the seed-based functional connectivity analysis in a relatively large sample of late adolescents, this study investigated the neural correlates of trait rumination and their associations with depressive symptoms. Results showed that higher functional connectivity between the left dorsal medial prefrontal cortex (DMPFC) and middle cingulate cortex (MCC) was positively associated with trait rumination. Additionally, stronger FC between the left DMPFC and the right inferior parietal lobe (IPL) was also related to trait rumination. Furthermore, logistic regression analysis indicated that FC strength between the left DMPFC and MCC was significantly associated with depressive symptom severity. These findings suggest DMPFC-related network may reflect neural mechanisms linked to both trait rumination and depressive symptoms in late adolescence.
基于任务的功能神经成像显示，沉思与默认模式网络（DMN）中的功能激活相关。本研究旨在检验DMN内的静息态功能连接（FC）是否与特质沉思的个体差异相关。本研究在相对较大的青少年晚期样本中使用基于种子点的功能连接分析，调查了特质沉思的神经关联及其与抑郁症状的关联。结果显示，左背内侧前额叶皮质（DMPFC）与中扣带回皮质（MCC）之间较高的功能连接与特质沉思呈正相关。此外，左DMPFC与右顶下叶（IPL）之间较强的FC也与特质沉思有关。此外，逻辑回归分析表明，左DMPFC与MCC之间的FC强度与抑郁症状严重程度显著相关。这些发现表明，与DMPFC相关的网络可能反映了与青少年晚期特质沉思和抑郁症状相关的神经机制。
