Aga Merga Abdissa, Woldeamanuel Berhanu Teshome
Department of Statistics, Salale University, Fiche, Ethiopia
Department of Epidemiology and Biostatistics, St Paul's Hospital Millennium Medical College, Addis Ababa, Addis Ababa, Ethiopia.
BMJ Paediatr Open. 2025 Aug 4;9(1):e003732. doi: 10.1136/bmjpo-2025-003732.
Low birth weight (LBW), defined as birth weight less than 2500 g regardless of gestational age, remains a pressing global health issue. It significantly contributes to neonatal mortality (60-80% of deaths), developmental delays and increased risk of chronic diseases in adulthood. Despite interventions, LBW remains prevalent in Ethiopia. This study aimed to identify the key risk factors for LBW in public hospitals in Addis Ababa, with a focus on maternal nutrition and prenatal care two underexplored but modifiable determinants: maternal nutrition and prenatal care.
A cross-sectional study was conducted in 2024 using data from 722 mothers selected via simple random sampling across four public hospitals in Addis Ababa. Birth weight was categorised into low and not low groups. To account for hospital-level variability, a multilevel binary logistic regression model was employed, treating hospitals as random effects, to identify maternal, nutritional and prenatal care factors associated with LBW.
The prevalence of LBW was 12%. The multilevel binary logistic regression model revealed significant between-hospital variability in LBW outcomes (variance=0.25; 95% CI: 0.12 to 0.55). Increased odds of LBW were associated with maternal age>34 years (adjusted OR (AOR)=2.51; 95% CI: 1.20 to 5.50), unplanned pregnancy (AOR=1.60; 95% CI: 1.42 to 1.92), family size >4 (AOR=2.15; 95% CI: 1.35 to 3.45), alcohol use during pregnancy (AOR=1.62; 95% CI: 1.28 to 2.01), delayed antenatal care initiation in the third trimester (AOR=1.14; 95% CI: 1.02 to 1.62) and heavy maternal workload (AOR=1.12; 95% CI: 1.01 to 1.64). Protective factors included regular antenatal care follow-up (AOR=0.29; 95% CI: 0.12 to 0.64), eating extra meals during pregnancy (AOR=0.46; 95% CI: 0.22 to 0.87), interpregnancy interval>24 months (AOR=0.55; 95% CI: 0.29 to 0.69), maternal height≥155 cm (AOR=0.49; 95% CI: 0.22 to 0.87) and pre-pregnancy weight≥50 kg (AOR=0.20; 95% CI: 0.06 to 0.46).
This study underscores that maternal age, pregnancy planning, family size, antenatal care access and timing, workload, alcohol use and nutritional practices are associated with LBW. The observed variation across hospitals suggests institutional differences may also influence outcomes. Strengthening maternal health programmes and improving hospital-level care could reduce LBW prevalence in Addis Ababa.
低出生体重(LBW)定义为无论孕周如何,出生体重低于2500克,它仍然是一个紧迫的全球健康问题。它是新生儿死亡(占死亡人数的60 - 80%)、发育迟缓以及成年后患慢性病风险增加的重要原因。尽管采取了干预措施,但低出生体重在埃塞俄比亚仍然普遍存在。本研究旨在确定亚的斯亚贝巴公立医院低出生体重的关键风险因素,重点关注孕产妇营养和产前护理这两个尚未充分探索但可改变的决定因素:孕产妇营养和产前护理。
2024年进行了一项横断面研究,使用通过简单随机抽样从亚的斯亚贝巴的四家公立医院选取的722名母亲的数据。出生体重分为低出生体重组和非低出生体重组。为了考虑医院层面的变异性,采用了多水平二元逻辑回归模型,将医院视为随机效应,以确定与低出生体重相关的孕产妇、营养和产前护理因素。
低出生体重的患病率为12%。多水平二元逻辑回归模型显示,低出生体重结果在医院之间存在显著差异(方差 = 0.25;95%置信区间:0.12至0.55)。低出生体重几率增加与以下因素相关:母亲年龄>34岁(调整后的比值比(AOR)= 2.51;95%置信区间:1.20至5.50)、意外怀孕(AOR = 1.60;95%置信区间:1.42至1.92)、家庭规模>4(AOR = 2.15;95%置信区间:1.35至3.45))、孕期饮酒(AOR = 1.62;95%置信区间:1.28至2.01)、孕晚期延迟开始产前护理(AOR = 1.14;95%置信区间:1.02至1.62)以及母亲工作量大(AOR = 1.12;95%置信区间:1.01至1.64)。保护因素包括定期进行产前护理随访(AOR = 0.29;95%置信区间:0.12至0.64)、孕期加餐(AOR = 0.46;95%置信区间:0.22至0.87)、两次怀孕间隔>24个月(AOR = 0.55;95%置信区间:0.29至0.69)、母亲身高≥155厘米(AOR = 0.49;95%置信区间:0.22至0.87)以及孕前体重≥50千克(AOR = 0.20;置信区间:0.06至0.46)。
本研究强调母亲年龄、怀孕计划、家庭规模、产前护理的可及性和时间安排、工作量、饮酒以及营养习惯与低出生体重有关。各医院之间观察到的差异表明机构差异也可能影响结果。加强孕产妇健康计划并改善医院层面的护理可以降低亚的斯亚贝巴的低出生体重患病率。