Hama Tomoaki, Kakuta Takatoshi, Amano Kazushige, Ushijima Akiko, Yoshimachi Fuminobu, Ikari Yuji
The Division of Cardiology, Department of Medicine, Tokai University Hachioji Hospital, Hachioji, Tokyo, Japan.
The Division of Nephrology, Endocrinology and Metabolism, Department of Medicine, Tokai University Hachioji Hospital, Hachioji, Tokyo, Japan.
Ther Apher Dial. 2025 Dec;29(6):856-865. doi: 10.1111/1744-9987.70069. Epub 2025 Aug 4.
Little is known about the effect of cardiac rehabilitation (CR) on cardiovascular events in patients with advanced chronic kidney disease (CKD).
We performed a retrospective cohort study in 189 patients with an estimated glomerular filtration rate of less than 30 mL/min/1.73 m who were referred to our outpatient CR center. They were divided into two groups according to whether they participated in CR or not, and compared for major adverse cardiovascular events (MACEs) incidences.
There were 143 that participated in CR and 46 that did not. The cumulative MACE rates in the participation group were lower than in the non-participation group (48% vs. 61%, p = 0.015). The hazard ratio for all-cardiovascular events in the participation group as compared to the non-participation group after adjusting for confounders was 0.56 (95% CI, 0.35-0.89, p = 0.014).
CR might reduce MACEs in patients with advanced CKD.
关于心脏康复（CR）对晚期慢性肾脏病（CKD）患者心血管事件的影响，目前所知甚少。
我们对189名估算肾小球滤过率低于30 mL/min/1.73 m²且被转诊至我们门诊CR中心的患者进行了一项回顾性队列研究。根据他们是否参与CR将其分为两组，并比较主要不良心血管事件（MACEs）的发生率。
143人参与了CR，46人未参与。参与组的累积MACE率低于未参与组（48%对61%，p = 0.015）。在调整混杂因素后，参与组与未参与组相比，全心血管事件的风险比为0.56（95%CI，0.35 - 0.89，p = 0.014）。
CR可能降低晚期CKD患者的MACEs。
