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Macrophages say NO to nucleotide synthesis and salvage instead.

作者信息

Marques Eloïse, Ryan Dylan G

机构信息

MRC Mitochondrial Biology Unit, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.

出版信息

Nat Metab. 2025 Aug 4. doi: 10.1038/s42255-025-01322-w.

DOI:10.1038/s42255-025-01322-w
PMID:40759750
Abstract
摘要

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本文引用的文献

[1]
Pyruvate dehydrogenase operates as an intramolecular nitroxyl generator during macrophage metabolic reprogramming.

Nat Commun. 2023-8-22

[2]
An integrated toolbox to profile macrophage immunometabolism.

Cell Rep Methods. 2022-4-25

[3]
Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase.

Nat Commun. 2020-2-4

[4]
Coupling Krebs cycle metabolites to signalling in immunity and cancer.

Nat Metab. 2019-1

[5]
Human and murine macrophages exhibit differential metabolic responses to lipopolysaccharide - A divergent role for glycolysis.

Redox Biol. 2019-2-20

[6]
Itaconate: the poster child of metabolic reprogramming in macrophage function.

Nat Rev Immunol. 2019-5

[7]
Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages.

Cell Rep. 2016-10-11

[8]
Metabolic Needs and Capabilities of Toxoplasma gondii through Combined Computational and Experimental Analysis.

PLoS Comput Biol. 2015-5-22

[9]
Macrophage activation and polarization: nomenclature and experimental guidelines.

Immunity. 2014-7-17

[10]
Epigenetic silencing of the human NOS2 gene: rethinking the role of nitric oxide in human macrophage inflammatory responses.

J Immunol. 2014-1-29

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